Cover; Half Title; Title Page; Copyright Page; Dedication; Table of Contents; Preface; Acknowledgement; Chapter 1: Introduction to Pathogenesis; Introduction; Henle-Koch postulates and evolving views of infectious disease causation; Experimental models of pathogenicity; The ethics of using humans, animals and cell lines in pathogenics research; Advantages and disadvantages of human experimentation in the study of the pathogenesis of infectious diseases; Animal models in the study of the pathogenesis of infectious diseases
Other considerations in experimental models of the pathogenesis of infectious diseasesHuman cell lines as a surrogate for microbe-host interactions; Bibliography; Chapter 2: Normal Microbiotas of the Human Body; Introduction; Microbiota of the skin; Microbiota of the vagina; Microbiota of the urinary tract; Microbiota of the conjunctiva; Respiratory tract microbiota; Microbiota of the alimentary canal; Mouth; Oesophagus; Stomach; Small intestine; Large intestine; Key concepts; Bibliography; Chapter 3: Biofilms; Introduction; Biofilms structure and properties; Mucosae versus skin
Initial steps in biofilm formationBiofilm development and the climax community; Quorum sensing in biofilms; Biofilm dispersal; Biofilms in human infections; Peripheral and central i.v. catheters; Urinary catheters; Bladder biofilms; Endotracheal tubes; Peritoneal cavity dialysis catheters; Prosthetic joints; Heart valves; Chronic wounds; Otitis media; Cystic fibrosis; Biofilm formation by filamentous fungi; Biofilm formation by viruses; How biofilms are studied; Key concepts; Bibliography; Chapter 4: Adhesion to Host Surfaces; Introduction; Barrier epithelia; Skin; Mucous membranes (mucosae)
