| Description |
1 online resource : illustrations |
| Contents |
Front Cover; The Molecular and Clinical Pathology of Neurodegenerative Disease; The Molecular and Clinical Pathology of Neurodegenerative Disease; Copyright; Contents; Preface; Acknowledgments; 1 -- AN INTRODUCTION TO NEURODEGENERATION; 1.1 WHAT IS NEURODEGENERATION?; 1.2 HOW TO USE THIS TEXTBOOK; 1.3 THE FUNDAMENTALS OF NEUROANATOMY; 1.4 A BEGINNER'S GUIDE TO BRAIN CELLS; 1.5 CLINICAL TOOLS; 1.6 METHODS AND MODELS FOR INVESTIGATING NEURODEGENERATION; 1.7 DRUGS, DRUG DEVELOPMENT, AND CLINICAL TRIALS; 1.8 SUMMARY; FURTHER READING; REFERENCES; 2 -- ALZHEIMER'S DISEASE AND DEMENTIA |
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2.1 INTRODUCTION2.2 CLINICAL PRESENTATION; 2.2.1 ALZHEIMER'S DISEASE; 2.2.2 VASCULAR DEMENTIA; 2.2.3 POSTERIOR CORTICAL ATROPHY; 2.2.4 LOGOPENIC APHASIA; 2.2.5 DYSEXECUTIVE OR FRONTAL VARIANT; 2.2.6 DIAGNOSIS OF ALZHEIMER'S DISEASE; 2.2.7 MANAGEMENT; 2.2.8 FRONTOTEMPORAL DEMENTIA; 2.2.9 BEHAVIORAL VARIANT FRONTOTEMPORAL DEMENTIA; 2.2.10 LANGUAGE VARIANT; 2.2.11 DOWN SYNDROME AND TRISOMY 21; 2.2.12 DEMENTIA WITH LEWY BODIES; 2.2.13 CHRONIC TRAUMATIC ENCEPHALOPATHY; 2.2.14 OTHER DEMENTIA SYNDROMES; 2.3 PATHOLOGY; 2.3.1 NEURONAL LOSS; 2.3.2 AMYLOID PLAQUES AND NEUROFIBRILLARY TANGLES |
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2.3.3 LEWY BODIES2.3.4 GLIAL PATHOLOGY; 2.3.5 TAUOPATHIES; 2.3.6 OTHER PATHOLOGIES; 2.4 MOLECULAR MECHANISMS OF DEGENERATION; 2.4.1 NEUROGENETICS; 2.4.1.1 Mendelian Forms of Alzheimer's-APP, PSEN1, PSEN2; 2.4.1.2 Other Mendelian Genes; 2.4.1.3 Risk Factors; 2.4.2 ANIMAL AND CELLULAR MODELS FOR DISEASE; 2.4.3 PROTEIN AGGREGATION AND DISEASE; 2.4.4 THE AMYLOID CASCADE; 2.4.5 MOLECULAR MECHANISMS DRIVING NEURODEGENERATION; 2.4.6 PROTEIN AGGREGATE SPREAD; 2.4.7 NEUROINFLAMMATION AND IMMUNE RESPONSE; 2.4.8 INTERPLAY BETWEEN GENETICS, PATHOLOGY, AGING, AND SPORADIC DISEASE; 2.5 THERAPIES |
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2.5.1 EXISTING THERAPIES2.5.2 DRUG DISCOVERY; 2.5.2.1 Targeting Amyloid Beta Production; 2.5.2.2 Removing Amyloid Beta; 2.5.3 TARGETING TAU; 2.5.4 INTERVENING IN NEUROINFLAMMATION AND THE IMMUNE RESPONSE; 2.5.5 OTHER STRATEGIES; 2.5.6 WHY ARE DRUGS FAILING?; 2.6 CONCLUSIONS; REFERENCES; 3 -- PARKINSON'S DISEASE; 3.1 INTRODUCTION; 3.2 CLINICAL PRESENTATION; 3.2.1 MOTOR SYMPTOMS; 3.2.2 NONMOTOR SYMPTOMS; 3.2.2.1 Neuropsychiatric; 3.2.2.2 Autonomic; 3.2.2.3 Sleep Disturbance; 3.2.2.4 Sensory; 3.2.2.5 Anosmia; 3.2.3 DEMENTIA AND PARKINSON'S DISEASE; 3.2.4 PROGRESSION/PROGNOSIS |
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3.2.5 PROGRESSIVE SUPRANUCLEAR PALSY AND MULTIPLE SYSTEM ATROPHY3.2.5.1 Progressive Supranuclear Palsy; 3.2.5.2 Multiple System Atrophy; 3.3 PATHOLOGY; 3.3.1 NIGRAL DEGENERATION; 3.3.2 LEWY BODIES; 3.3.4 DOPAMINERGIC NETWORKS; 3.3.5 BEYOND THE SUBSTANTIA NIGRA; 3.3.6 BEYOND LEWY BODIES; 3.4 MOLECULAR MECHANISMS OF DEGENERATION; 3.4.1 GENETICS; 3.4.1.1 Protein Aggregation/Proteostasis; 3.4.1.2 Mitochondrial Dysfunction; 3.4.1.3 Inflammation; 3.4.2 ENVIRONMENTAL ROUTES TO PARKINSONISM; 3.4.2.1 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine; 3.4.2.2 Rotenone and Paraquat |
| Summary |
The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Nervous system -- Degeneration.
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Nervous system -- Diseases -- Pathophysiology
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Nervous system -- Diseases.
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Nervous System Diseases
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Nervous system -- Degeneration
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| Form |
Electronic book
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| Author |
Spillane, Jennifer E., author
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| ISBN |
9780128110706 |
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0128110708 |
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