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Book Cover
E-book
Author Shaw, Christopher A

Title Spectrums of Amyotrophic Lateral Sclerosis Heterogeneity, Pathogenesis and Therapeutic Directions
Published Newark : John Wiley & Sons, Incorporated, 2021

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Description 1 online resource (237 p.)
Contents Cover -- Title Page -- Copyright Page -- Contents -- Contributors -- Foreword -- Preface -- Acknowledgments -- Chapter 1 Clinical Heterogeneity of ALS -- Implications for Models and Therapeutic Development -- Introduction -- Clinical Heterogeneity of ALS -- Familial and Sporadic ALS -- Age of Onset -- Survival -- Classic ALS, LMN Form, and UMN Form -- Site of Onset -- Diagnosis of ALS -- ALS and Its Relationship with Frontotemporal Dementia and Myopathies -- Pleiotropy of ALS Genes -- Genetic Models to Study ALS -- In Vivo Models -- In Vitro Models -- Conclusion -- Conflict of Interest
Copyright and Permission Statement -- References -- Chapter 2 Genetic Basis of ALS -- Introduction -- Genes Causing ALS -- Superoxide Dismutase 1 (SOD1) -- TAR DNA-Binding Protein 43 (TDP-43) -- Fused in Sarcoma (FUS) -- Chromosome 9 Open Reading Frame 72 (C9orf72) -- Recently Discovered Genes -- Annexin A11 (ANXA11) -- Glycosyltransferase 8 Domain Containing 1 (GLT8D1) -- Stathmin-2 (STMN2) -- Aspects of ALS Heritability -- Sporadic vs. Familial -- Penetrance and the Oligogenic Hypothesis -- Multistep Model -- Noncoding Variation -- Regulatory and Intronic Variants -- Epigenetics -- Conclusions
Acknowledgments -- Conflict of Interest -- Copyright and Permission Statement -- References -- Chapter 3 Susceptibility Genes and Epigenetics in Sporadic ALS -- Introduction -- Environmental Associations in sALS -- Genetic Basis of sALS -- Identification of sALS Susceptibility Genes -- Candidate sALS Susceptibility Genes -- UNC13A -- DPP6 -- C21orf2 -- Epigenetic Mechanisms in sALS -- Methylation in sALS -- miRNAs in sALS -- Post-Translational Histone Modification in sALS -- Epigenetic Analysis in Monozygotic sALS Twins -- Modifications to the Epigenome by Environmental Factors
In Utero Environmental Exposures -- Environmental in Utero Epigenomic Alterations -- Post Utero Exposures -- Conclusion -- Conflict of Interest -- Copyright and Permission Statement -- References -- Chapter 4 The Lessons of ALS-PDC -- Environmental Factors in ALS Etiology -- Introduction -- Koch's Postulates in the Search of Etiological ALS Factors -- Neurological Disease Clusters -- The Natural History of ALS-PDC -- Investigating Etiological Factors -- Identified Cycad toxin/Toxicants -- Aluminum and Ionic Etiologies for ALS-PDC -- Other Molecules That Might Have Been Involved in ALS-PDC
A Putative Viral Etiology for ALS-PDC on Guam and ALS in General -- The Continuing Importance of ALS-PDC -- Summary and Conclusions -- Acknowledgments -- Conflict of Interest -- Copyright and Permission Statement -- Note -- References -- Chapter 5 The Microbiome of ALS -- : Does It Start from the Gut? -- Introduction -- Recent Studies -- Animal and in vitro Studies -- Clinical Studies -- How Could the Microbiome Contribute to ALS? -- Gut Barrier and Membrane Permeability -- Inflammation and Immune Response -- Neurotoxins -- Energy Metabolism
Notes Description based upon print version of record
Microbiome Modulation as a Potential Therapeutic Avenue
Form Electronic book
Author Morrice, Jessia R
ISBN 9781119745501
1119745500