| Description |
1 online resource |
| Series |
Cell biology research progress |
| Contents |
Preface; Chapter 1; Caspases: A Driver in Programmed Cell Death; Abstract; 1. Introduction; 2. History of Caspases; 3. Role of Caspases in Apoptosis; 4. Initiator Caspases; 5. Executioner Caspases; 6. Apoptosis Pathways; 6.1. The Extrinsic Route of Apoptosis; 6.1.1. Death Receptor (DR) Pathway of Apoptosis; 6.1.2. Ligand Death Receptor; 6.2. The Intrinsic Route of Apoptosis; 7. Types of Caspase; 7.1. Caspase-1; 7.2. Caspase-2; 7.3. Caspase-3; 7.4. Caspase-6; 7.5. Caspase-7; 7.6. Caspase-8; 7.7. Caspase-9; 7.8. Caspase-10; 7.9. Caspase-12; 7.10. Caspase-14 |
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8. Comparison of Caspase-1, -4, -59. Cellular Proliferation; 9.1. Cellular Differentiation; 9.2. Apoptosis and Immuno-Suppression; 10. General Caspase Inhibition In Vivo; 11. Caspases in Sub-Cellular Compartments; Conclusion and Future Perspectives; References; Chapter 2; Caspases Importance in Cell Death and Disease; Abstract; 1. Introduction; 2. Apoptosis; 3. Necrosis; 4. Caspases Structure; 5. Apoptotic Role; 6. Non Apoptotic Role; 7. Immune Function; 8. An Inflammatory Microenvironment; 9. Mechanisms of Substrate Recognition; 10. Human Caspases; 11. Activity of Caspases in Inflammation |
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12. Function of Pattern-Recognition Receptors13. Caspases in Proliferation; 14. Cell Migration; 15. Cell Differentiation; 16. Dimerisation; 17. Cleavage; 18. Caspases in Human Disease; 18.1. Cancer; 18.2. Inflammatory Diseases; 18.3. Gout; 18.4. Cryopyrin-Associated Periodic Syndromes; 18.5. Type 2 Diabetes; 18.6. Familial Mediterranean Fever; 18.7. Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, and Acne Syndrome; 18.8. Hyperimmunoglobulinemia D with Periodic Fever Syndrome; 18.9. Trypanosoma Cruzi Infection; Conclusion and Future Perspectives; References; Chapter 3 |
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The Role of Executioner Caspases in Cancer Formation and MaintenanceAbstract; 1. Introduction; 2. Caspase Family; 2.1. Structural Considerations of Human Executioner Caspases; 2.2. Caspase Substrates; 2.3. Caspase Active Sites; 2.4. Caspase Exosites; 2.5. Caspase Dimerization; 2.6. Executioner Caspase Activation by Proteolysis; 2.7. Caspase Allosteric Sites; 2.8. Post-Translational Modification; 2.8.1. Ubiquitylation; 2.8.2. Phosphorylation; 2.8.3. Nitrosylation; 2.8.4. Acetylation; 2.9. Cellular Localization; 3. Caspase Gene Expression; 3.1. Splice Variants of Executioner Caspases |
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4. Caspase Deficiencies in Cancer4.1. Expression of Caspase Inhibitory Pathways -- Upstream (MOMP) and Downstream (IAPs); 5. Mammalian Models Interrogating Pathophysiological Roles of Executioner Caspases; Conclusion; References; Supplementary Resources; Biographical Sketch; Chapter 4; The Unknown Caspase: The Role of Caspase-14 in Cell Death and Disease; Abstract; Introduction; Caspase-14: Discovery and Structure; The Role of Caspase-14 in Cell Death; The Role of Caspase-14 in Disease; Caspase-14 Protects Against Common Skin Conditions; Caspase-14 Is Implicated in Disorders of the Eye |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Description based on print version record and CIP data provided by publisher |
| Subject |
Apoptosis.
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Cell death.
|
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SCIENCE / Life Sciences / Anatomy & Physiology
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Apoptosis
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Cell death
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| Form |
Electronic book
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| Author |
Warren, Jeffrey S., editor
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| LC no. |
2016044447 |
| ISBN |
9781536102604 |
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1536102601 |
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