Title Matrix metalloproteinase inhibitors : specificity of binding and structure-activity relationships / Satya Prakash Gupta, editor

Published Basel ; New York : Springer, ©2012

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Description 1 online resource (x, 285 pages) Series Experientia supplementum, 1023-294X ; v. 103 Experientia. Supplementum ; v. 103. Contents Matrix Metalloproteinases / Viola Vargová, Marek Pytliak and Viola Mechírová -- Specificity of Binding with Matrix Metalloproteinases / Satya P. Gupta and Vaishali M. Patil -- The Gelatinases and Their Inhibitors: The Structure-Activity Relationships / Snehasikta Swarnakar, Amartya Mishra and Susri Ray Chaudhuri (Guha) -- Advances in Studies on Collagenase Inhibitors / Mange Ram Yadav, Prashant Revan Murumkar and Vishal Prakash Zambre -- Hydroxamic Acids as Matrix Metalloproteinase Inhibitors / Rajeshwar P. Verma -- Quantitative Structure-Activity Relationship Studies on Sulfonamide-Based MMP Inhibitors / Vaishali M. Patil and Satya P. Gupta -- Matrix Metalloproteinase Inhibitors as Investigative Tools in the Pathogenesis and Management of Vascular Disease / Mina M. Benjamin and Raouf A. Khalil Summary Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results in tissue degradation, producing a wide array of disease processes such as rheumatoid arthritis, osteoarthritis, tumor growth and¡metastasis, multiple sclerosis, congestive heart failure, and others. Thus MMP inhibitors are candidates for therapeutic agents to combat a number of diseases. ¡ The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases. The articles focus specifically on structure-activity relationships of all classes of compounds and on their modes of action and specificity of binding with the receptors based on experimental and theoretical studies. These studies constitute a valuable asset for all those involved in drug development Analysis Medicine Neurosciences Biomedicine biomedische wetenschappen neurowetenschap neuroscience Medicine (General) Geneeskunde (algemeen) Bibliography Includes bibliographical references and index Notes English Subject Metalloproteinases -- Inhibitors Extracellular Matrix Proteins Matrix Metalloproteinases MEDICAL -- Nutrition. Metalloproteinases -- Inhibitors Matrixproteine Metalloproteinaseninhibitor Form Electronic book Author Gupta, Satya Prakash. ISBN 9783034803649 3034803648 1280786744 9781280786747 9786613697134 6613697133

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