| Description |
1 online resource (242 pages) |
| Contents |
Cover; Half Title Page; Title Page; Copyright Page; About the Author; Table of Contents; List of Figures; List of Tables; List of Abbreviations; Preface; Introduction: Basics and Tracks of Cell Signaling; References; Chapter 1 Growth Factors and Tyrosine Kinase Receptors; 1.1. General Characteristics of the GF-TKR Interrelationship; 1.2. The Paradigmatic Model of the EGF (ERBB) Family; 1.3. Other Families of GFS and Growth Factor Receptors; 1.4. Tyrosine Phosphatase Receptors; Further Reading; Chapter 2 Map Kinase Pathway; 2.1. From Receptor Stimulation to RAS Activation; 2.2. Kinase Cascade |
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2.3. Other Signaling Elements2.4. Map Kinase Substrates; 2.5. Oncogenic Changes; 2.6. Pharmacological Targeting; Further Reading; Chapter 3 Phosphatidylinositol 3-Kinase Pathway; 3.1. From Phosphatidylinositol 3-Kinase to AKT Proteins; 3.2. AKT Proteins and Their Substrates; 3.3. mTOR Protein and The TORC Complexes; 3.4. Oncogenic Alterations; 3.5. Pharmacological Targets; Further Reading; Chapter 4 G-Protein-Coupled Receptors; 4.1. Structure And Mechanism of Action of G-Protein-Coupled Receptors; 4.2. Second Messengers of GPCR Activation; 4.3. Oncogenic Changes And Pharmacological Targeting |
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Further ReadingChapter 5 TGFß Pathway; 5.1. TGFß Family Ligands; 5.2. Receptors Activation; 5.3. Signal Transduction In The TGFß Pathway; 5.4. Oncogenic Changes; 5.5. Pharmacological Targeting; Further Reading; Chapter 6 Cytokines Pathway; 6.1. Cytokines; 6.2. Cytokine Receptors and JAK Activation; 6.3. Signal Processing; 6.4. Oncogenic Changes; 6.5. Pharmacological Targeting; Further Reading; Chapter 7 Cell Cycle Control; 7.1. Cell Cycle Phases; 7.2. Effector Proteins of Cell Cycle Regulation; 7.3 Control of Cell Cycle Progression; 7.4. Oncogenic Changes In Cell Cycle Regulation |
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7.5. Pharmacological TargetingFurther Reading; Chapter 8 WNT Pathway; 8.1. WNT Ligands and Their Receptors; 8.2. WNT-ß-Catenin Pathway; 8.3. 'Non-Canonical' WNT Pathways; 8.4. Oncogenic Changes; 8.5. Pharmacological Targeting; Further Reading; Chapter 9 Notch Pathway; 9.1. DSL Ligands; 9.2. Notch Receptors; 9.3. Notch Receptor Activation And Signal Transduction; 9.4. Oncogenic Changes; 9.5. Pharmacological Targeting; Further Reading; Chapter 10 Ion Channel-Coupled Receptors; 10.1. Activation Of Ligand-Gated Ion Channels; 10.2. Purinergic Receptors; 10.3. Ca2+ Signaling; Further Reading |
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Chapter 11 Apoptosis Process and Regulation11.1. Proteins Implicated In Apoptosis; 11.2. Intrinsic (Mitochondrial) Apoptosis Pathway; 11.3. Extrinsic (Death Receptor) Apoptosis Pathway; 11.4. Oncogenic Alterations Of Apoptosis Pathways; 11.5. Pharmacological Targets; 11.6. Dependence Receptors; Further Reading; Chapter 12 Hedgehog Pathway; 12.1. Hedgehog Ligands; 12.2. Patched Receptors and Their Activation; 12.3. HHG Signal Transmission; 12.4. Oncogenic Changes; 12.5. Pharmacological Targeting; Further Reading; Chapter 13 Integrins; 13.1. Integrins And Integrin Ligands |
| Notes |
13.2. Signaling Pathways Starting From Integrins |
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Print version record |
| Subject |
Cellular signal transduction.
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Signal Transduction
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Cellular signal transduction
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| Form |
Electronic book
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| ISBN |
1773618202 |
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9781773618203 |
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