| Description |
1 online resource (381 p.) |
| Series |
Advances in Bionanotechnology Series |
|
Advances in Bionanotechnology Series
|
| Contents |
Cover -- Half Title -- Series Information -- Title Page -- Copyright Page -- Dedication -- Table of Contents -- Preface -- Aim and Scope -- List of Contributors -- About the Editors -- Acknowledgements -- 1 Nanomedicine at the Forefront: Transforming Brain Drug Delivery With Innovative Strategies -- 1.1 Introduction -- 1.2 Classification of Nanoparticles -- 1.2.1 Inorganic Nanoparticles -- 1.2.2 Polymeric Nanoparticles -- 1.2.3 Lipid-Based Nanoparticles -- 1.3 Physicochemical Properties of Nanoparticles -- 1.4 Promising Strategies for Enhancing Central Nervous System Drug Delivery |
|
1.4.1 Liposomes -- 1.4.2 Viral Vectors -- 1.4.3 Nanoemulsion -- 1.4.4 Solid Lipid Nanoparticles -- 1.4.5 Polymeric Micelles -- 1.4.6 Niosomes -- 1.4.7 Dendrimers -- 1.4.8 Silica Nanoparticles -- 1.4.9 Gold Nanoparticles -- 1.5 Conclusions and Future Prospects -- References -- 2 Brain Diseases: An Introduction and the Need for Novel Drug-Delivery Approaches -- 2.1 Introduction -- 2.2 The Blood-Brain Barrier -- 2.2.1 Brain Microvascular Endothelial Cells -- 2.2.2 Astrocytes -- 2.2.3 Pericytes -- 2.2.4 Tight Junction Proteins -- 2.2.5 ABC Transporters -- 2.3 Variables Impacting Delivery to the Brain |
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2.4 Disruption of the Blood-Brain Barrier in Certain Pathological Conditions -- 2.4.1 Neurodegenerative Diseases -- 2.4.2 Brain Tumor -- 2.4.3 Infection -- 2.5 Current Strategies for Brain Drug Delivery -- 2.5.1 Transport of Substances Across the Blood-Brain Barrier -- 2.5.1.1 Simple and Facilitated Diffusion -- 2.5.1.2 Carrier-Mediated Transport -- 2.5.1.3 Receptor-Mediated Transport -- 2.5.1.4 Adsorptive-Mediated Transcytosis -- 2.5.1.5 Cell-Mediated Transport -- 2.5.1.6 Peptide-Vector-Mediated Transport -- 2.5.2 Recent Strategies for Delivering Drugs Into the Brain |
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2.5.2.1 Administration Aiming for Systemic Delivery -- 2.5.2.2 Direct Central Nervous System Delivery -- 2.5.2.3 BBB Disruption Approach -- 2.5.2.4 Chemistry-Based Approach -- 2.5.2.5 Biotechnology-Based Approach -- 2.5.2.6 Delivery Through the Autonomous Nervous System -- 2.5.2.7 Recent Pharmaceutical Formulations for Delivering Drugs -- 2.6 Conclusion and Future Insights -- References -- 3 Advanced Drug-Delivery Systems for Brain Diseases Across the Blood-Brain Barrier -- 3.1 Introduction -- 3.1.1 Targeting Concepts for Drug Delivery -- 3.1.1.1 Passive Targeting -- 3.1.1.2 Active Targeting |
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3.1.1.3 Intracellular Targeting -- 3.2 Functionalization Concepts for Enhanced Brain Targeting -- 3.2.1 Ligand-Mediated Targeting -- 3.2.2 Antibody-Mediated Targeting -- 3.2.3 PH-Sensitive Functionalization -- 3.3 Advanced Technologies for Enhancing Drug Delivery Through BBB -- 3.3.1 Ultrasound-Mediated BBB Disruption -- 3.3.2 Microbubble-Mediated -- 3.3.3 Magnetophoretic Mediated -- 3.3.4 Laser-Guided Technology -- 3.3.5 Transcranial Magnetic Stimulation (TMS) -- 3.4 Advanced Drug Delivery Systems for Brain Disease -- 3.4.1 Exosomes -- 3.4.2 Biomimetic Nanoparticles |
| Notes |
Description based upon print version of record |
|
3.4.3 Magnetic-Targeting Delivery Systems |
| Form |
Electronic book
|
| Author |
Chaturvedi, Vivek K
|
|
Singh, Jay
|
| ISBN |
9781003851844 |
|
1003851843 |
|
