| Description |
1 online resource : illustrations |
| Contents |
Section 1. Ideas and methods for the modern research of TCM formulas. Chapter 1. Strategy for modern research of traditional Chinese medicine formulae -- Chapter 2. Theories and methods for the evaluation of the pharmacodynamic material basis of traditional Chinese medicine -- Chapter 3. Application of systems biology in the research of TCM formulae -- Chapter 4. Network pharmacology in the study of TCM formulae -- Chapter 5. Application of intestinal flora in the study of TCM formulae -- Chapter 6. Application of connectivity map (CMAP) database to research on traditional Chinese medicines (TCMs) -- Section 2. Case study on Shexiang Baoxin pill. Chapter 7. The study of the material basis of the Shenxiang Baoxin pill -- Chapter 8. Study on the serum pharmacochemistry of the Shenxiang Baoxin pill -- Chapter 9. The quality study of the Shenxiang Baoxin pill -- Chapter 10. Pharmacokinetic study of the Shenxiang Baoxin pill -- Chapter 11. The metabolomics study of the Shenxiang Baoxin pill -- Chapter 12. Network phramacology study of the Shenxiang Baoxin pill |
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Front Cover; Systems Biology and its Application in TCM Formulas Research; Copyright; Contents; Contributors; Introduction; Section 1: Ideas and Methods for the Modern Research of TCM Formulas; Chapter 1: Strategy for Modern Research of Traditional Chinese Medicine Formulae; 1.1. Current Research on TCM Formulae; 1.2. Principles for the Study of TCM Formulae; 1.2.1. Holism and Reductionism; 1.2.2. Macro- and Microstudies; 1.2.3. In Vitro and in vivo Studies; 1.3. Modern TCM Formulae Research; 1.3.1. Research on Therapeutic Materials Basis; 1.3.2. Modern Pharmacology |
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1.3.2.1. Top-Down: Holistic Pharmacology and Active Components Screening1.3.2.2. Bottom-Up: Pharmacological Evaluation of Key Active Components and Multicomponent Compatibility; 1.3.3. Systems Biology; 1.3.3.1. Genomics; 1.3.3.2. Proteomics; 1.3.3.3. Metabolomics; 1.3.3.4. Epigenomics; 1.3.3.5. Metagenomics; 1.4. Network Biology and TCM Network Pharmacology; References; Chapter 2: Theories and Methods for the Evaluation of the Pharmacodynamic Material Basis of Traditional Chinese Medicine; 2.1. The Development of Research on the Pharmacodynamic Material Basis of TCM |
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2.2. New Methods for the Study of the Pharmacodynamic Material Basis of TCM2.2.1. Combined Chemical Technologies for the Study of TCM; 2.2.2. Serum Pharmacology and Serum Pharmacochemistry Method; 2.2.3. Analysis of Spectrum-Effect Relationships; 2.2.4. HTS of Multiple Targets; 2.2.5. Molecular Biological Chromatography Technique; 2.2.6. Metabolism Method; 2.2.7. System Biology Method; References; Chapter 3: Application of Systems Biology in the Research of TCM Formulae; Abstract; Keywords; 3.1. Omics in Systems Biology; 3.1.1. Genomics; 3.1.1.1. Pharmacogenomics; 3.1.1.2. Metagenomics |
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3.1.1.3. Epigenomics3.1.2. Transcriptomics; 3.1.3. Proteomics; 3.1.3.1. Phosphoproteomics; 3.1.3.2. Glycoproteomics; 3.1.3.3. Chemoproteomics; 3.1.4. Metabolomics; 3.1.4.1. Pharmacometabolomics; 3.1.4.2. Lipidomics; 3.1.5. Other â#x80;#x9C;Omicsâ#x80;#x9D; Technologies; 3.1.5.1. Phenomics; 3.1.5.2. Immunomics; 3.1.5.3. Metallomics; 3.1.5.4. Cytomics; 3.1.5.5. Ionomics; 3.1.5.6. Interactomics; 3.2. Application of Systems Biology in the Research of TCM Formulae; 3.2.1. Action Mechanisms of TCM Formulae; 3.2.2. The Concept of a Syndrome in TCM; 3.2.3. Active Component Compatibility (or Synergy) in TCM Formulae |
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3.2.4. Pharmacokinetic Studies of TCM Formulae3.2.5. Discovery and Development of TCM-Based New Drugs; References; Chapter 4: Network Pharmacology in the Study of TCM Formulae; 4.1. Identification of Therapeutically Effective TCM Compounds; 4.2. Identification of the Targets of Active TCM Compounds; 4.2.1. Proteomic Technologies; 4.2.2. Computational Predictions; 4.2.3. Database Searching; 4.3. Identification of Disease-Associated Genes and Construction of Disease-Related Networks; 4.3.1. Identification of Disease-Associated Genes; 4.3.2. Construction of Disease Networks |
| Summary |
Systems Biology and Its Application in TCM Formulas Research presents a theoretical research system formed for Traditional Chinese Medicine (TCM) formulas, along with information on the study of Shexiang Baoxin Pill (SBP), a TCM formula that has shown significant clinical efficacy in the treatment of cardiovascular diseases. The content combines theory and practice, and includes guidance for both theoretical concepts and operable technical routes. This is a valuable source not only for biomedical researchers involved in Systems Biology studies, but also for students and scientists interested in learning more about Traditional Chinese Medicine and its applications in contemporary medicine |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (EBSCO, viewed February 21, 2018) |
| Subject |
Medicine, Chinese -- Formulae, receipts, prescriptions -- Research
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Medicine, Chinese -- Research
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Systems biology.
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Medicine, Chinese.
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Medicine, Chinese Traditional
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Drug Compounding
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Materia Medica
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Systems Biology
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MEDICAL -- Pharmacology.
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Medicine, Chinese
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Medicine, Chinese -- Research
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Systems biology
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| Form |
Electronic book
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| Author |
Zhang, Wei-Dong, editor
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| ISBN |
9780128127452 |
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0128127457 |
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