| Description |
1 online resource |
| Series |
Advances in pharmaceutical product development and research series |
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Advances in pharmaceutical product development and research series.
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| Contents |
Front Cover; Dosage Form Design Considerations; Copyright Page; Dedication; Contents; List of Contributors; About the Editor; 1 Preformulation in Drug Research and Pharmaceutical Product Development; 1.1 Introduction; 1.1.1 An Overview of Formulation Life Cycle and Management; 1.1.2 Need of Preformulation: First Stage of Formulation Development; 1.1.3 Major Hurdles Impeding Successful Product Development; 1.1.4 Role of Preformulation During Product Development; 1.2 Parameters of preformulation studies; 1.2.1 Solubility; 1.2.2 The Permeability of the Drug |
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1.2.3 Bulk Characterization: Physical, Analytical, and Physicochemical1.2.4 Inherent Properties: pH, pKa, Log P, Log D, and Intrinsic Dissolution; 1.2.5 Stability: The Solution, Solid State, & ICH Photostability; 1.2.6 Drug-Excipient Compatibility; 1.2.7 Particle Size and Distribution; 1.2.8 Thermal Properties; 1.2.9 Hygroscopicity; 1.2.10 Bulk Properties; 1.2.11 Mechanical Properties and Compatibility; 1.2.12 Crystallinity and Polymorphism; 1.3 Role of preformulation in drug discovery; 1.3.1 Material Properties in Lead Selection, High Throughput Preformulation Studies |
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1.3.2 "Drugability" of New Chemical Entities1.3.3 Tools to Assist in Lead Selection; 1.4 Role of preformulation in drug development; 1.4.1 Identification of Challenges During Formulation Development: Pre-Assumptions; 1.4.2 The Dosage Form Specific Studies; 1.5 Preformulation studies of proteins and peptides; 1.6 Preformulation in vaccine development: Critical views; 1.7 Preformulation studies of packaging components; 1.8 Preformulation in 21st century: technological advancements; 1.8.1 Computerization and Aid of Software in the Preformulation Studies |
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1.8.2 Artificial Neural Network Tool Used in the Factorial Design: An Optimization Approach1.9 Case studies on preformulation of dosage forms; 1.10 Pharmacokinetics and preformulation: Point to note; 1.11 Rules and regulations in preformulation studies: Role of regulatory bodies; 1.12 Future remarks and conclusion; Acknowledgment; Abbreviations; References; Further Reading; 2 Physicochemical Aspects to Be Considered in Pharmaceutical Product Development; 2.1 Introduction; 2.2 Physical Characteristics of Solid Substances Used in Pharmaceutical Product Development |
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2.2.1 Crystalline Solid-State Substances2.2.1.1 Polymorphism; 2.2.1.2 Hydrates; 2.2.1.3 Solvates; 2.2.1.4 Cocrystals; 2.2.2 Amorphous Solids; 2.2.3 Particle Size; 2.2.4 Wettability; 2.2.5 Hygroscopicity; 2.3 Chemical Characteristics to be Considered in Pharmaceutical Product Development; 2.3.1 Degradation Reactions of Drugs; 2.3.1.1 Hydrolysis; 2.3.1.2 Dehydration; 2.3.1.3 Oxidation; 2.3.1.4 Photochemical Degradation; 2.3.1.5 Isomerization; 2.3.1.6 Polymerization; 2.3.1.7 Other Reactions; 2.4 Solubility Aspects in Pharmaceutical Products Development; 2.4.1 Aqueous Solubility |
| Summary |
Dosage Form Design Parameters, Volume I, examines the history and current state of the field within the pharmaceutical sciences, presenting key developments. Content includes drug development issues, the scale up of formulations, regulatory issues, intellectual property, solid state properties and polymorphism. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of dosage form design parameters. Chapters delve into a particular aspect of this fundamental field, covering principles, methodologies and the technologies employed by pharmaceutical scientists. In addition, the book contains a comprehensive examination suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnology and related industries |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (EBSCO, viewed July 31, 2018) |
| Subject |
Drugs -- Dosage forms.
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Drugs -- Design.
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Drug development.
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Drug delivery systems.
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Dosage Forms
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Drug Compounding
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Drug Design
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Drug Delivery Systems
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MEDICAL -- Pharmacology.
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Drug delivery systems
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Drug development
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Drugs -- Design
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Drugs -- Dosage forms
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| Form |
Electronic book
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| Author |
Tekade, Rakesh K., editor
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| ISBN |
9780128144244 |
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0128144246 |
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