| Description |
1 online resource (279 p.) |
| Series |
Frontiers in Clinical Drug Research - CNS and Neurological Disorders Ser |
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Frontiers in Clinical Drug Research - CNS and Neurological Disorders Ser
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| Contents |
Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Preface -- List of Contributors -- Integrating Imaging and Microdialysis into Systems Neuropharmacology -- Carla Biesdorf1 and Robert E. Stratford1,* -- INTRODUCTION -- MICRODIALYSIS OVERVIEW -- INTEGRATION OF MICRODIALYSIS WITH PET IMAGING -- Measurement of Brain Metabolic Activity -- Demonstration of Drug Delivery to the Brain -- Demonstration of Drug Binding to Target by Displacement of Tracer Binding -- Alteration of Tracer Binding in Response to Drug Treatment and in Disease |
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Assessment of Neurotransmitter Concentrations -- INTEGRATION OF MICRODIALYSIS WITH MRI -- Microdialysis and Structural MRI -- Microdialysis and MRS -- Microdialysis and fMRI -- INTEGRATION OF MICRODIALYSIS AND EEG MONITORING -- Seizures -- Sleep Disorders -- Miscellaneous Diseases -- INTEGRATION OF MICRODIALYSIS WITH OTHER IMAGING MODALITIES -- Computed Tomography Imaging -- Mass Spectrometry Imaging -- SPECT Imaging -- INTEGRATED USE OF IMAGING AND MICRODIALYSIS IN ALZHEIMER'S DISEASE RESEARCH -- Pathology of AD -- Pharmacologic Treatment of AD -- Biomarkers of AD |
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Potential Applications for Integrated Use of Imaging and Microdialysis in AD Research -- SUMMARY AND CONCLUSIONS -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Depression Heterogeneity and the Potential of a Transdiagnostic and Dimensional Approach to Identify Biologically Relevant Phenotypes -- Zoya Marinova1,* -- INTRODUCTION -- THE HETEROGENEITY OF MAJOR DEPRESSIVE DISORDER -- MELANCHOLIC AND ATYPICAL DEPRESSION -- Biological Correlates of Melancholic and Atypical Depression -- Genetic Markers -- Biochemical Markers -- Treatment Response |
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DEPRESSION WITH MANIC OR HYPOMANIC SYMPTOMS -- Depression with Manic or Hypomanic Symptoms -- DATA-DRIVEN DEPRESSION SUBTYPES -- COMBINING BIOLOGICAL AND CLINICAL FINDINGS BASED ON THE TRANSDIAGNOSTIC DIMENSIONAL APPROACH APPLIED BY THE RESEARCH DOMAIN CRITERIA (RDOC) PROJECT -- THERAPEUTIC IMPLICATIONS OF THE HETEROGENEITY OF DEPRESSION -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- CAR-T Cells in Brain Tumors and Autoimmune Diseases -- from Basics to the Clinic |
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Mansour Poorebrahim1,*, Niloufar Mohammadkhani2,3, Mohammad Foad Abazari4, Elham Fakhr1,5, Isaac Quiros-Fernandez1,5, Solmaz Sadeghi6 and Angel Cid-Arregui1 -- 1. INTRODUCTION -- 2. DEVELOPMENTS IN CAR-T CELLS -- 2.1. CAR-T cell generations -- 2.2. Next-Generation CAR Platforms -- 3. VEHICLES FOR CAR DELIVERY -- 3.1. Viral Vectors -- 3.2. Non-Viral Technologies -- 4. PRODUCTION AND INFUSION OF CAR-T CELLS TO THE BRAIN -- 4.1. Isolation and Enrichment of T Cells -- 4.2. Activation of T Cells -- 4.3. Transduction of T Cells -- 4.4. Expansion of CAR-T Cells -- 4.5. Formulation of CAR-T Cells |
| Notes |
Description based upon print version of record |
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4.6. CAR-T Cell Infusion To The Brain |
| Form |
Electronic book
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| Author |
Amtul, Zareen
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| ISBN |
9781681089041 |
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1681089041 |
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