| Description |
1 online resource |
| Contents |
Inflammatory mechanisms in Alzheimer's disease and other neurodegenerative disorders / J. Rogers [and others] -- Treatment development strategies for Alzheimer's disease / E. Wülfert -- Lipoprotein-associated phospholipase A2 as a new prognostic factor for coronary artery disease / A. Tselepis -- Protein modifications by nitric oxide and reactive nitrogen species / H. Ischiropoulos -- Design, synthesis, and pharmacological evaluation of high affinity and selectivity sigma-1 and sigma-2 receptor ligands / J.H. Poupaert -- Synthesis of biologically active taxoids / K.C. Nicolaou and R.K. Guy -- From the molecular pharmacology to the medicinal chemistry of cannabinoids / D.M. Lambert -- New inhibitors of DNA topoisomerase in the treatment of experimental malignancies / C. Atassi -- Treatment of psoriasis with anthrones-biochemical aspects / W. Wiegrebe and K. Müller -- An appraisal of fomocaines, current situation, and outlook / H. Oelschläger and A. Seeling -- Ligands for the GABA recognition site at the GABAA receptor: structure-activity studies / B. Frølund [and others] -- Discovery of potent and selective inhibitors of human aldosterone synthase (CYP11B2): a new target for the treatment of congestive heart failure and myocardial fibrosis: a review / R.W. Hartmann [and others] |
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Thiocarboxanilides: a new class of non-nucleoside reverse transcriptase inhibitors (NNRTIS) with great potential for the treatment of human immunodeficiency virus type 1 (HIV-1) infections / E. De Clercq, A. Karlsson, and J. Balzarini -- Histamine H3-receptor agonists and antagonists: chemical, pharmacological, and clinical aspects / H. Stark and W. Schunack -- Anti-inflammatory actions of flavonoids and structural requirements / T. Theoharides -- Molecular mechanisms of H2O2-induced DNA damage: the action of desferrioxamine / M. Tenopoulou, P.-T Doulias, and D. Galaris -- LNA (locked nucleic acid) and functionalized LNA: towards efficient gene targeting / J. Wengel -- The effect of diet on drug metabolism / K.J. Netter -- Cytochromes P450 in the metabolism and bioactivation of chemicals / C. Ioannides -- In vitro methods to measure drug metabolism and metabolic interactions in drug discovery and development / O. Pelkonen [and others] -- How to probe the sites of action of drug molecules / A. Makriyannis and F. Bitter -- Lipophilicity as a descriptor of molecular properties in drug design / B. Testa [and others] -- Drug membrane interaction and the importance for drug transport, distribution, accumulation, efficacy, and resistance / J.K. Seydel [and others] -- Structure-based and computer-aided drug design / H. Kubinyi -- Physicochemical profiling in early drug discovery: new challenges at the age of high-throughput screen and combinatorial chemistry / B. Faller |
| Summary |
Drawing from synthetic chemistry, molecular modelling, computational biology, structural genomics, and pharmacology, this text explores medicinal chemistry. It focuses on the correlation of properties and biological activity, and delves into the phenomenon of xenobiotic metabolism |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Pharmaceutical chemistry.
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Drugs -- Design.
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Chemistry, Pharmaceutical
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Drug Design
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Pharmacologic Actions
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MEDICAL -- Drug Guides.
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MEDICAL -- Pharmacology.
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MEDICAL -- Pharmacy.
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MEDICAL -- Nursing -- Pharmacology.
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Drugs -- Design
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Pharmaceutical chemistry
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| Form |
Electronic book
|
| Author |
Rekka, E. A
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Kourounakis, P. N
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| ISBN |
9781420008272 |
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1420008277 |
|
1281274437 |
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9781281274434 |
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