| Description |
1 online resource (812 pages) |
| Contents |
880-01 Intro; Volume 1; Title Page; Copyright Page; Contents; List of Contributors; Foreword; Part 1 Basic Concepts; Chapter 1 Contributions of Plasma Protein Binding and Membrane Transporters to Drug-Induced Mitochondrial Toxicity; 1.1 Drug Accumulation; 1.2 Small Molecule Delivery to Tissues; 1.3 Entry into Cells; 1.4 Transport Out of Cells; 1.5 Entry into Mitochondria; 1.6 Export from Mitochondria; 1.7 Concluding Remarks; References; Chapter 2 The Role of Transporters in Drug Accumulation and Mitochondrial Toxicity; 2.1 Introduction to Chapter; 2.2 The Solute Carrier (SLC) Superfamily |
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880-01/(S Chapter 5 Mitochondrial Dysfunction in Drug-Induced Liver Injury5.1 Introduction; 5.2 Structure and Physiological Role of Mitochondria; 5.2.1 Structure and Main Components of Mitochondria; 5.2.2 Oxidation of Pyruvate and Fatty Acids; 5.2.3 Production of ATP; 5.2.4 Production of ROS as Signaling Molecules; 5.3 Main Consequences of Hepatic Mitochondrial Dysfunction; 5.3.1 Consequences of Mitochondrial β-Oxidation Inhibition; 5.3.2 Consequences of MRC Inhibition; 5.3.3 Consequences of Mitochondrial Membrane Permeabilization; 5.4 Main Hepatotoxic Drugs Inducing Mitochondrial Dysfunction |
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2.3 Transporters as Determinants of Drug Levels in Tissues and Subcellular Compartments2.4 Drug Transporters in the Intestine; 2.5 Drug Transporters in the Liver; 2.6 Drug Transporters in the Kidney; 2.6.1 Conservation Mechanisms; 2.6.2 Detoxification Mechanisms; 2.7 Mitochondrial Transporters; 2.8 Conclusions; References; Chapter 3 Structure-Activity Modeling of Mitochondrial Dysfunction; 3.1 Introduction; 3.1.1 Mitochondrial Structure and Function; 3.1.2 Mechanisms of Mitochondrial Toxicity; 3.2 Mitochondrial Toxicity Data Sources; 3.2.1 Zhang Dataset; 3.2.2 ToxCast Data |
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3.3 In Silico Modeling of Mitochondrial Toxicity3.3.1 Statistical Modeling; 3.3.2 Structural Alert Modeling; 3.4 Mechanistic Chemistry Covered by the Existing Structural Alerts; 3.5 Structural Alert Applicability Domains: Physicochemical Properties; 3.6 Future Direction: Structure-Activity Studies for Other Mechanisms of Mitochondrial Toxicity; 3.7 Concluding Remarks; References; Chapter 4 Mitochondria-Targeted Cytochromes P450 Modulate Adverse Drug Metabolism and Xenobiotic-Induced Toxicity; 4.1 Introduction; 4.2 Multiplicity of Mitochondrial CYPs |
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4.3 Targeting and Significance of Multiple Forms of Mitochondrial CYPs4.3.1 Mitochondrial Import of CYP1A1; 4.3.2 Mitochondrial Import of CYP1B1; 4.3.3 Mitochondrial Import of CYP2C8; 4.3.4 Mitochondrial Import of CYP2D6; 4.3.5 Mitochondrial Import of CYP2B1 and CYP2E1; 4.3.6 Import Mechanism of GSH-Conjugating GSTA4-4; 4.4 Variations in Mitochondrial CYPs and Drug Metabolism; 4.5 Physiological and Toxicological Significance of Mitochondria-Targeted CYPs; 4.6 Mitochondrial CYPs and Cell Signaling; 4.7 Conclusion; Acknowledgment; References; Part 2 Organ Drug Toxicity: Mitochondrial Etiology |
| Notes |
5.4.1 Acetaminophen |
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Print version record |
| Subject |
Drugs -- Toxicology.
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Mitochondrial pathology.
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Drugs -- Toxicology
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Mitochondrial pathology
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| Form |
Electronic book
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| Author |
Dykens, James A
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| ISBN |
9781119329732 |
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1119329736 |
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