| Description |
1 online resource (ix, 561 pages) : illustrations (some color) |
| Series |
Healthy ageing and longevity ; volume 18 |
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Healthy ageing and longevity ; v. 18.
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| Contents |
Intro -- Preface -- Contents -- Part I Understanding Sleep and Clock Interlink in Health and Longevity -- 1 Sleep and Circadian Clock: Novel Players in Health Impacts and Aging -- 1.1 Introduction -- 1.2 Sleep -- 1.2.1 What is Sleep? -- 1.2.2 Physiological Basis of Sleep -- 1.2.3 Types of Sleep/Different Stages of Sleep -- 1.2.4 Sleep Duration/Need -- 1.2.5 Regulation of Sleep -- 1.3 Biological Clock: Circadian Timing System (CTS) -- 1.3.1 SCN: Neurotransmitters in Input and Output Pathways -- 1.3.2 SCN: Relay Center for Information -- 1.3.3 Melatonin: Messenger of Darkness |
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1.3.4 Molecular Components of CTS -- 1.4 Sleep and Circadian Rhythms: Interplay -- 1.4.1 The Two-Process Model: The Interaction of Circadian Forces and Sleep Homeostasis -- 1.4.2 Sleep Gate -- 1.5 Sleep and Clock Misalignment with Aging -- 1.5.1 Alterations in Sleep Structure in Old -- 1.5.2 Desynchronization of Circadian Rhythm Patterns in Old -- 1.5.3 The Circadian and Sleep Perturbances -- 1.6 Interventions to Improve Sleep and Clock Function: A Step Toward Healthy Aging and Longevity -- 1.6.1 Sleep Hygiene -- 1.6.2 Light Therapy -- 1.6.3 Administration of Exogenous Melatonin |
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1.6.4 Herbal and Other Interventions -- 1.7 Goals and Conclusions -- References -- 2 Cells and Circuits of the Suprachiasmatic Nucleus and the Control of Circadian Behaviour and Sleep -- 2.1 Introduction: Mammalian Circadian System Overview -- 2.2 Molecular-Genetic and Cellular Basis of Circadian Timekeeping in Mammals -- 2.2.1 The Core Feedback Loop-Genes and Molecules: Discoveries Through Mapping and Mutagenesis Screens -- 2.2.2 Additional Feedback Loops Support the TTFL -- 2.2.3 Control of the Stability of Clock Proteins and Effect on Behaviour -- 2.3 Circadian Properties of SCN Neurons |
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2.3.1 Observing Clock Proteins at the Cellular Level -- 2.3.2 SCN Neural Activity and Transcriptional Cycles -- 2.3.3 The Importance of Coupling Between SCN Neurons -- 2.4 Circuit Architecture of the SCN as a Neuronal Network -- 2.4.1 Entrainment of the SCN Network: Photic and Non-photic Cues -- 2.4.2 SCN Network Synchrony: GABA and Neuropeptides -- 2.4.3 VIP Axis: Mediator of SCN Photic Entrainment and Neuronal Synchrony -- 2.4.4 GRP Axis: An Accessory Entrainment and Synchronisation Pathway -- 2.4.5 AVP Axis: Within-Shell Coupling and Circadian Output |
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2.4.6 Prokineticin-2 Axis: More Than an SCN Output? -- 2.4.7 An Emerging View of the Functional Topology of the SCN Network -- 2.5 The Role of Astrocytes in the SCN -- 2.5.1 Astrocytic Control of Circadian Rhythms -- 2.5.2 Astrocyte-To-Neuron-To-Astrocyte Communication Within the SCN Network -- 2.6 SCN Outputs and Control of Circadian Behaviour and Sleep -- 2.6.1 SCN Outputs and Control of Circadian Behaviour -- 2.6.2 SCN in the Circadian Regulation of Sleep -- 2.7 Conclusion and Future Perspectives -- References -- 3 Circadian Regulation of Sleep -- 3.1 Introduction |
| Summary |
This edited volume focuses on the interplay between sleep and circadian rhythms with health, aging and longevity. Sleep is absolutely important for human health and survival, as insufficient sleep is associated with a plethora of conditions, including the poor quality of life, onset of several diseases, and premature death. The sleepwake cycle is an evolutionary conserved neurobiological phenomenon, and is a prominent manifestation of the biological clocks localised in the suprachiasmatic nucleus (SCN). Understanding bidirectional relationship between sleep and circadian rhythms is of utmost importance and urgency, especially in the context of modern lifestyle where sleep is often out of phase with the internal body clocks, social jetlag, artificial lights and so on. The 25 chapters by leading researchers and experts from 11 countries are arranged into seven sections: understanding sleep and clock interlink in health and longevity; sleep, aging and longevity; clock, aging and longevity; melatonin, sleep and clock; genetic regulation of sleep and clock; therapeutic interventions in sleep disorders and clock misalignment; and experimental models to study sleep and clocks in aging and longevity. This book is useful for advanced undergraduate and graduate students, and researchers, educators, and other biomedical professionals. |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed March 16, 2023) |
| Subject |
Aging -- Physiological aspects
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Circadian rhythms -- Health aspects
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Aging -- Physiological aspects
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| Form |
Electronic book
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| Author |
Jagota, Anita, editor
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| ISBN |
9783031224683 |
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303122468X |
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