| Description |
1 online resource (512 pages) |
| Contents |
Intro; Preface to the First Edition; Preface to the Second Edition; Contents; 1: Drug Interactions and Pharmacogenetics; 1.1 Introduction; 1.2 Principles of Drug Interactions; 1.2.1 Physical Interactions or Chemical Incompatibilities; 1.2.1.1 pH Effects; 1.2.1.2 Solubilizers; 1.2.1.3 Plasticizers; 1.2.1.4 Sorption; 1.2.2 Chemical Reactions; 1.2.3 Denaturation; 1.2.4 Pharmacokinetic Interactions; 1.2.4.1 Absorption; 1.2.4.2 Ionization; 1.2.5 Complexation; 1.2.5.1 Contact with the Digestive Mucosa; 1.2.5.2 Gastrointestinal Motility; Modifications in Drug Diffusion |
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1.2.6 Binding to Plasma Proteins1.2.6.1 Modification of the Tissue Binding; Metabolic Interactions; Modifications in the Elimination; Miscellaneous; 1.2.7 Pharmacodynamic Interactions; 1.2.7.1 Terminology; 1.2.7.2 Synergy and Antagonism; 1.2.7.3 Enhancement and Antagonism; 1.3 Interactions Between Anticancer Drugs and Other Active Substances; 1.3.1 Antiemetics; 1.3.1.1 Chlorpromazine; 1.3.1.2 Metoclopramide; 1.3.1.3 Granisetron and Ondansetron; 1.3.2 Antiulcer Drugs; 1.3.3 Analgesics (Nonsteroidal Anti-inflammatory Drugs); 1.3.4 Antimicrobial Agents; 1.3.5 Miscellaneous |
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1.4 Anticancer Drug-Anticancer Drug Interactions1.4.1 Modulation; 1.4.2 Undesired Drug Interactions; 1.5 Drug Interactions Between Anticancer Drugs and Resistance-Modifying Agents; 1.6 Pharmacogenetics; 1.7 Summary; References; 2: Breast Cancer; 2.1 Introduction; 2.2 Chemotherapy; 2.2.1 Classes of Chemotherapy and General Toxicities; 2.2.1.1 Anti-microtubule Agents (Taxanes, Ixabepilone, Eribulin, and Vinca Alkaloids); 2.2.1.2 Anthracyclines (Doxorubicin, Epirubicin, Mitoxantrone, Liposomal Doxorubicin, and Non-pegylated Liposomal Doxorubicin) |
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2.2.1.3 Antimetabolites (5-Fluorouracil, Methotrexate, Capecitabine, and Gemcitabine)2.2.1.4 Alkylating Agents (Cyclophosphamide, Cisplatin, and Carboplatin); 2.2.1.5 Dose-Dense Chemotherapy; 2.2.2 Incidence and Management of Selected Chemotherapy Toxicities; 2.2.2.1 Febrile Neutropenia; 2.2.2.2 Management of Chemotherapy-Induced Emesis; 2.2.2.3 Peripheral Neuropathy; 2.2.2.4 Cardiac Failure; 2.2.2.5 Gastrointestinal Side Effects: Mucositis, Diarrhea, and Constipation; 2.2.2.6 Cognitive Dysfunction; 2.2.2.7 Altered Body Image and Sexual Dysfunction; 2.2.2.8 Fertility |
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2.2.2.9 Secondary Malignancies2.3 Endocrine Therapies; 2.3.1 Gynecological Side Effects; 2.3.2 Thromboembolic Disease; 2.3.3 Hot Flashes; 2.3.4 Eye Problems; 2.3.5 Musculoskeletal Pain; 2.3.6 Bone Loss; 2.3.7 Cardiovascular Events; 2.3.8 Cognitive Dysfunction; 2.4 Targeted Agents; 2.4.1 Cardiovascular Toxicity; 2.4.2 Hypertension; 2.4.3 Infusion Reactions; 2.4.4 Hepatotoxicity; 2.4.5 Gastrointestinal Perforation, Wound-Healing Complications, and Bleeding; 2.4.6 Diarrhea; 2.4.7 Skin Rash; 2.4.8 Interstitial Pneumonitis; 2.4.9 Hematological Toxicity |
| Summary |
Designed as a quick reference for oncologists, this handbook covers the side-effects of cancer therapy drugs, including chemotheraputic drugs. Organised by organ system, the text discusses treatment toxicity and side-effects, in addition to measures of prevention for each type of cancer therapy drug |
| Bibliography |
Includes bibliographical references and index |
| Notes |
2.5 Bone-Modifying Agents |
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Print version record |
| Subject |
Cancer -- Chemotherapy -- Complications.
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Drugs -- Side effects.
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Drug interactions.
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Antineoplastic Agents -- adverse effects
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Drug Interactions
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Drug-Related Side Effects and Adverse Reactions -- prevention & control
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Drug-Related Side Effects and Adverse Reactions
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Drug interactions
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Cancer -- Chemotherapy -- Complications
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Drugs -- Side effects
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| Form |
Electronic book
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| Author |
Dicato, Mario, editor
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Cutsem, Eric van, editor
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| ISBN |
9783319702537 |
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331970253X |
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