Title Clinical ethics at the crossroads of genetic and reproductive technologies / edited by Sorin Hostiuc

Edition First edition Published London, United Kingdom ; San Diego, CA, United States : Academic Press, an imprint of Elsevier, [2018]

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Description 1 online resource Contents Front Cover; Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies; Copyright; Contents; Contributors; Chapter 1: Genomic Editing-From Human Health to the "Perfect Child; 1. Introduction; 1.1. Definitions and Context; 1.2. Recombinant DNA Technology-The Basis for DNA Modification; 1.3. Genome Editing; 1.3.1. Meganucleases; 1.4. Zinc Finger Nucleases (ZFNs); 1.4.1. Transcription-Activator Like Nucleases (TALENs); 1.5. CRISPR/Cas9 Technology; 1.6. Base Editing Technology; 1.7. Principles of Using Genome Editing in Research and Clinical Practice 2. Ethical Issues in Clinical Genome Editing 2.1. Nonmaleficence and Risk/Benefit Assessment; 2.1.1. Risk to Benefit Analysis; 2.2. Beneficence in Gene-Editing Therapies; 2.3. Respect for Autonomy; 2.4. Confidentiality; 2.4.1. Germline Editing; 2.5. Applying the Principle of Justice in Clinical Genome Editing; 2.6. Eugenics, Enhancement, and "Designer Babies; 3. Conclusions; References; Further Reading; Chapter 2: Ethics of Mitochondrial Gene Replacement Therapy; 1. Introduction; 2. What Is Mitochondrial Disease and Mitochondrial Donation?; 3. The UK Timeline; 4. The International Position 5. Are the Techniques Safe? 6. Ethical Issues; 7. "Three-Parent Babies" and Identity; 8. Genetic Modification and the ̀̀Slippery Slope;́́ 9. Donating Eggs (Risks and Benefits); 10. Differences Between PNT and MST; 11. Mitochondrial Disease as Complex: Diagnosis, Predicting Risk, and Genetic Counseling; 12. Alternative Reproductive Options; 13. Polar Body Transfer and Gene Editing; 14. Conclusion; References; Further Reading; Chapter 3: Reproductive Technologies Used by Same Gender Couples; 1. Introduction; 2. Procreative Autonomy; 3. Gamete and Embryo Donation; 4. Surrogacy Agreement 5. Transgender Parenthood 6. Conscience Clause; 7. Conclusions; References; Further Reading; Chapter 4: Ethical Issues Raised by Multiparents*; 1. Introduction; 1.1. Key Terms in the Debate: Filiation, Kinship, and Parenthood; 2. Multiparents of Children Born Through ARTs; 2.1. Maternity; 2.2. Paternity; 3. Where Do All These Parents Come From?; 3.1. Sperm Donation; 3.2. Egg Donation; 3.3. Embryo Donation; 3.4. Surrogacy; 4. Ethical Issues; 4.1. The Right to Know One's Origins; 4.2. Donors Anonymity; 4.3. The Consent of Participants; 5. Secondary Ethical Issues; 5.1. Medical Tourism 5.2. Slippery Slope 6. Final Considerations; References; Further Reading; Chapter 5: Revisiting the Nondirective Principle of Genetic Counseling in Prenatal Screening; 1. Introduction; 2. Historical Background and Implementation of Public Policy for Prenatal Screening; 3. Ethical References in the Development of Screening Tests; 4. Genetic Consultation in Prenatal Screening: Nondirective and Neutral?; 5. Nondirective Consultation Challenged or an Opportunity to Support Reproductive Autonomy by Complete Balanced Information? Summary Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies offers thorough discussions on preconception carrier screening, genetic engineering and the use of CRISPR gene editing, mitochondrial gene replacement therapy, sex selection, predictive testing, secondary findings, embryo reduction and the moral status of the embryo, genetic enhancement, and the sharing of genetic data. Chapter contributions from leading bioethicists and clinicians encourage a global, holistic perspective on applied challenges and the moral questions relating the implementation of genetic reproductive technology. The book is an ideal resource for practitioners, regulators, lawmakers, clinical researchers, genetic counselors and graduate and medical students. As the Human Genome Project has triggered a technological revolution that has influenced nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, prenatal genetic testing, and gene therapy, this book presents a timely resource Bibliography Includes bibliographical references and index Notes Online resource; title from digital title page (viewed on September 21, 2018) Subject Human genetics -- Moral and ethical aspects. Genetic engineering -- Moral and ethical aspects Human reproductive technology -- Moral and ethical aspects Medical ethics. Medical innovations -- Moral and ethical aspects Human Genetics -- ethics Ethics, Medical BUSINESS & ECONOMICS -- Business Ethics. Human reproductive technology -- Moral and ethical aspects Human genetics -- Moral and ethical aspects Genetic engineering -- Moral and ethical aspects Medical ethics Medical innovations -- Moral and ethical aspects Form Electronic book Author Hostiuc, Sorin, editor ISBN 9780128137659 0128137657

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