| Description |
1 online resource (556 p.) |
| Contents |
Intro -- Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies -- Copyright -- Contents -- Contributors -- Chapter 1: Genomic editing: From human health to the ̀̀perfect child ́́ -- 1. Introduction -- 1.1. Beginnings -- 1.2. Definitions and context -- 1.3. Recombinant DNA technology: The basis for DNA modification -- 1.4. Genome editing -- 1.4.1. Meganucleases -- 1.5. Zinc finger nucleases (ZFNs) -- 1.5.1. Transcription activator-like nucleases (TALENs) -- 1.6. CRISPR/Cas9 technology -- 1.7. Base editing technology |
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1.8. Principles of using genome editing in research and clinical practice -- 2. Ethical issues in clinical genome editing -- 2.1. Nonmaleficence and risk/benefit assessment -- 2.1.1. Risk-to-benefit analysis -- 2.2. Beneficence in gene editing therapies -- 2.3. Respect for autonomy -- 2.4. Confidentiality -- 2.4.1. Germline editing -- 2.4.2. The He Jiankui affair and the aftermath -- 2.5. Applying the principle of justice in clinical genome editing -- 2.6. Eugenics, enhancement, and ̀̀designer babies ́́ -- 3. Conclusions -- References -- Chapter 2: Ethics of mitochondrial gene replacement therapy |
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1. Introduction -- 2. What is mitochondrial disease and mitochondrial donation? -- 3. The UK timeline -- 4. The international position -- 5. Are the techniques safe? -- 6. Ethical issues -- 7. ̀̀Three parent babies ́́and identity -- 8. Genetic modification and the ̀̀slippery slope ́́ -- 9. Risks for egg donors -- 10. Ethical differences between PNT and MST -- 11. Mitochondrial disease as complex: Diagnosis, predicting risk, and genetic counseling -- 12. Alternative reproductive options -- 13. Polar body transfer and gene editing -- 14. Conclusion -- References -- Further reading |
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Chapter 3: Reproductive technologies used by same-gender couples -- 1. Introduction -- 2. Procreative autonomy -- 3. Gamete and embryo donation -- 4. Surrogacy agreement -- 5. Trans parenthood -- 6. Conscience clause -- 7. Conclusions -- References -- Further reading -- Chapter 4: Ethical issues raised by multiparents -- 1. Introduction -- 1.1. Key terms of the debate: Filiation, kinship, and parenthood -- 2. Multiparents of children born through ARTs -- 2.1. Maternity -- 2.2. Paternity -- 3. Where do all these parents come from? -- 3.1. Sperm donation -- 3.2. Egg donation -- 3.3. Embryo donation |
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3.4. Surrogacy -- 4. Ethical issues -- 4.1. The right to know ones origins -- 4.2. Donors anonymity -- 4.3. The consent of participants -- 5. Secondary ethical issues -- 5.1. Medical tourism -- 5.2. Slippery slope -- 6. Final considerations -- References -- Chapter 5: Revisiting the nondirective principle of genetic counseling in prenatal screening -- 1. Introduction -- 2. Genetic counseling: An overview -- 3. The nondirective principle in genetic counseling -- 3.1. ̀̀Nondirectivity ́́or ̀̀sharing decision-making?́́ |
| Notes |
Description based upon print version of record |
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3.2. The nondirective principle of genetic counseling in preimplantation screening |
| Form |
Electronic book
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| ISBN |
9780443190469 |
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0443190461 |
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