| Description |
1 online resource (256 p.) |
| Series |
Frontiers in Cardiovascular Drug Discovery Ser |
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Frontiers in Cardiovascular Drug Discovery Ser
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| Contents |
Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Preface -- List of Contributors -- Cardiovascular Effects of Ranolazine and the Scope for Translational Research: A Current Review of Literature -- Rebecca Pratiti1,*, Parul Sud1, Mohammad Yousef1 and Ankush Moza2 -- RANOLAZINE -- MECHANISM OF ACTION -- Effects on Late Sodium Current -- Effect on Metabolism -- Dosage Formulations, Pharmacodynamics and Pharmacokinetics -- Side Effects -- General Side Effects -- Tolerability of Ranolazine -- Drug-drug Interaction -- QT-prolonging Effects -- Animal Studies |
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CHRONIC STABLE ANGINA (CSA) -- ACUTE CORONARY SYNDROME (ACS) -- ATRIAL FIBRILLATION -- Rhythm Control for Atrial Fibrillation in the Presence and Absence of other Medications -- Post-operative Atrial Fibrillation (POAF) in Patients Undergoing Cardiac Surgery -- CARDIOMYOPATHY -- Chemotherapy-induced Cardiomyopathy -- Hypertrophic Cardiomyopathy -- ARRHYTHMIAS -- LONG QT SYNDROMES (LQTS 3) -- Pathophysiology -- Efficacy -- HEART FAILURE (HF) -- Pathophysiology -- Heart Failure with Preserved Ejection Fraction (Diastolic) -- Heart Failure With Reduced Ejection Fraction (Systolic) |
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GLYCEMIC EFFECTS -- Mechanism of Action -- Effect on Glycated Hemoglobin A1c (HbA1c) -- Modifier effect of Metformin -- OTHER ADDITIONAL EFFECTS OF RANOLAZINE -- FUTURE IMPLICATIONS -- Gaps in Translational Research -- Possible Causes of Inefficacy in Studies -- CONCLUSION AND SUMMARY -- LIST OF ABBREVIATIONS -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENTS -- REFERENCES -- Rho/Rho Kinase Signaling Pathway and Disease: from Bed to Bench -- Yiming Wang1,#, Yuqing Zhang2,# and Dingguo Zhang3,* -- INTRODUCTION -- BIOLOGICAL EFFECTS OF RHO PROTEIN -- Rho Protein Classification |
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Rho Protein Structure and Activity Regulation -- Downstream Effector Molecules of Rho -- RHO KINASE -- Structure and Classification of Rho Kinases -- Regulation Mechanism of Rho Kinase Activity -- Rho Kinase Inhibitor -- RHO/RHO KINASE AND CARDIOVASCULAR DISEASE -- Rho/Rho Kinase and Hypertension -- Rho/Rho Kinase and Pulmonary Hypertension -- Rho/Rho Kinase and Atherosclerosis -- Rho/Rho Kinase and Myocardial Ischemia Reperfusion Injury -- Rho/Rho Kinase and Adriamycin-induced Heart Injury -- Outlook -- RHO KINASE AND ISCHEMIC CEREBROVASCULAR DISEASE |
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The Mechanism of Rho Kinase in Cerebral Ischemia -- Rho Kinase Mediates Oxidative Stress -- Rho Kinase Mediated Cytoskeleton Changes -- Rho Kinase Mediates Inflammatory Response -- Rho Kinase Regulates Phosphatidylinositol Metabolism -- Rho Kinase Regulates the Expression of eNOS -- Rho Kinase Regulates the Expression of Matrix Metalloproteinase-9 -- Neuroprotective Effect of Rho Kinase Inhibitor -- Outlook -- RHO KINASE AND RESPIRATORY DISEASES -- Rho Kinase and COPD -- Rho Kinase and Asthma -- Rho Kinase and IPF -- Rho Kinase and Lung Cancer -- Conclusion and Prospect |
| Summary |
Frontiers in Cardiovascular Drug Discovery is a book series devoted to publishing the latest advances in cardiovascular drug design and discovery. Each volume brings reviews on the biochemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships of molecules used in cardiovascular therapy. The book series should prove to be of great interest to all medicinal ch |
| Notes |
Description based upon print version of record |
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RHO KINASES IN IMMUNE CELLS AND AUTOIMMUNE DISEASES |
| Form |
Electronic book
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| ISBN |
9789815036909 |
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9815036904 |
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