| Description |
1 online resource |
| Contents |
Intro -- Foreword -- Foreword -- Foreword -- Preface -- Contents -- Chapter 1: Introduction -- References -- Chapter 2: Genetics in Unusual Facial Clefts -- 2.1 Introduction -- 2.2 Inheritance in Humans -- 2.3 Orofacial Clefts -- References -- Chapter 3: Mechanisms, Etiology, and Classification of Rare Clefts -- 3.1 Introduction -- 3.2 Normal Biology -- 3.2.1 Craniofacial Phylogenesis -- 3.2.2 Craniofacial Ontogenesis -- 3.2.2.1 At the Gastrulation Stage -- Midline Organization: The Primitive Streak [6] -- Ectoderm Patterning -- 3.2.2.2 Neurulation |
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The Discovery and Studies of Neural Crest Cells [1, 11] -- Neural Crest Cells Individualization [13] -- Neural Crest Cells Survival -- Apoptosis of NCCs -- NCCs Migration (Fig. 3.6) -- Genetic Coding Affecting NCC Mobility -- Cells Deformability -- Cells Adhesion -- Epithelial-Mesenchymal Transition -- Filopodial Motility -- Paths Followed by NCCs -- Neural Crest Cells Patterning and Differentiation -- Genetic Coding Affects the Patterning Capacity of Surface Cranial Ectoderm -- Pax6 and the Lambda Junction [26] |
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Positioning the Articulation Between Mandible and Maxillary: The Hinge and Cap Model [27] -- Fgf8 and the Frontonasal Process -- Patterning Role of the Foregut Endoderm -- Closure of the Neural Tube -- 3.2.2.3 Facial Buds: The Facial Primordia (Fig. 3.8a) -- 3.2.2.4 The Role of Primary Cilia -- 3.2.2.5 Fetal Vascularization -- Segmentation -- 3.3 Pathology -- 3.3.1 The Terminology for Birth Defects (Fig. 3.10) -- 3.3.2 The Agents of Birth Defects -- 3.3.2.1 Environmental Causes of Birth Defects (Fig. 3.11) -- 3.3.2.2 Genetic Causes of Birth Defects (Figs. 3.12 and 3.13) |
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3.3.3 The Targets of Birth Defects -- 3.3.3.1 Midline Organization -- Midline Duplication -- Midline Dysraphia -- Midline Defect -- 3.3.3.2 Malformations Due to Neural Crest Cells Anomalies -- Perturbation in NCCs Multiplication and Apoptosis -- Perturbations in NCCs Migration (Fig. 3.13) -- Perturbation Affecting NCC at their Arrival Location (Fig. 3.13) -- 3.3.3.3 Complex Conditions of Unknown Origin -- Amniotic Band Syndrome/ADAM/LWD -- Pathogenic Hypothesis for ABS -- ABS is Considered a Disruption Caused by Amniotic Anomalies -- The Streeter Hypothesis |
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3.3.3.4 Amniotic Bands as Part and Not the Cause of the Syndrome -- The Vascular Hypothesis -- 3.3.3.5 Mice Disorganization Mutation -- 3.4 Classification of Rare Clefts -- 3.4.1 Morian's Classification [114] (Fig. 3.17) -- 3.4.2 Grünberg's Classification [116] -- 3.4.3 Classification of the American Association for Cleft Palate Rehabilitation [117] (Fig. 3.18) -- 3.4.4 The Frontonasal Dysplasia and Its Subtypes -- 3.4.5 Tessier's Classification -- 3.4.6 Whitaker's Classification -- 3.4.7 Van der Meulen, Mazzola, and Stricker's classification [133] (Fig. 3.20) |
| Summary |
Facial cleft is one of the most common congenital anomalies while atypical facial clefts are rare, with an incidence of 1.43 and 4.85 in 100,000 births. This book is dedicated exclusively to the diagnosis and treatment of rare facial clefts. It provides a comprehensive review of clinical aspects and surgical approaches used in unusual facial clefts and associated syndromes. Moreover, presents different classifications and surgical techniques, reflecting the authors extensive experience with a broad cross-section of treated patients. The rich illustrations and computed tomography images allows a broad view, helping the reader to understand the conduct in complex cases. Facial Reconstruction of Unusual Facial Clefts is an indispensable reference for all healthcare professionals involved in the multidisciplinary treatment of patients with craniofacial anomalies |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed December 21, 2023) |
| Subject |
Cleft lip -- Surgery
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Cleft palate -- Surgery
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Surgery, Plastic.
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Cleft lip -- Surgery.
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Cleft palate -- Surgery.
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Surgery, Plastic.
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| Form |
Electronic book
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| Author |
Alonso, Nivaldo.
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Freitas, Renato da Silva
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Tonello, Cristiano
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Pellerin, Philippe
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| ISBN |
9783031409264 |
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3031409264 |
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