| Description |
1 online resource (xiii, 317 pages) : illustrations |
| Series |
AAPS Advances in the Pharmaceutical Sciences Series, 2210-7371 ; 7 |
|
AAPS advances in the pharmaceutical sciences series ; 7.
|
| Contents |
Membrane Transporters in ADME / Bente Steffansen -- In Vitro Kinetic Characterization of Transporter-Mediated Permeability / Bente Steffansen -- In Vitro Characterization of Interactions with Drug Transporting Proteins / Per Artursson, Pär Matsson and Maria Karlgren -- In Vivo Characterization of Interactions on Transporters / Hiroyuki Kusuhara, Kenta Yoshida and Yuichi Sugiyama -- Applications of Targeted Proteomics in ADME for IVIVE / Larissa M. Balogh and Yurong Lai -- Prediction of Hepatic Transporter-Mediated Drug-Drug Interaction from In Vitro Data / Kazuya Maeda and Yuichi Sugiyama -- Accounting for Transporters in Renal Clearance: Towards a Mechanistic Kidney Model (Mech KiM) / Sibylle Neuhoff, Lu Gaohua, Howard Burt and Masoud Jamei -- Analysis of Intestinal Transporters / Ikumi Tamai and Takeo Nakanishi -- Analysis of Hepatic Transport Proteins / Kyunghee Yang and Kathleen Köck -- Analysis of Renal Transporters / Frans G.M. Russel and Rosalinde Masereeuw -- The Role of Transporters in Drug Development: Regulatory Science Perspectives from the FDA / Lei Zhang and Shiew-Mei Huang -- Industrial Evaluation of Drug Transporters in ADME / Mitchell E. Taub, Naoki Ishiguro and Olaf Schaefer |
|
Membrane Transporters in ADME -- In Vitro Characterization of Transporter Mediated Permeability -- In Vitro Characterization of Interactions with Drug Transporting Proteins -- In Vivo Characterization of Interactions on Transporters -- Application of Targeted Proteomics in ADME for IVIVE -- Prediction of Transporter Mediated Drug-Drug Interaction from In Vitro Data -- Accounting for Transporters in Renal Clearance: Towards a Mechanistic Kidney Model (Mech KiM) -- Analysis of Intestinal Transporters -- Analysis of Hepatic Transport Proteins -- Analysis of Renal Transporters -- The Role of Transporters During Drug Development: Regulatory Science Perspective from the FDA -- Industrial Evaluation of Drug Transporters in ADME |
| Summary |
Transporters in Drug Development is a corner stone in a high profile book series on advances in pharmaceutical sciences initiated by AAPS, Springer and Professor Daan Crommelin as series Editor. Transporters in Drug Development: Discovery, Optimization, Clinical Study and Regulation list chapters written by leading researchers in the transporter field from academia, pharmaceutical industry and medicines agencies. The book encompasses examples and advises on how membrane transporters can be dealt with in academic industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. Methods and examples of in vitro characterization of single transporters in intestine, liver and kidney are described as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are discussed as well as the perspectives of applying targeted proteomics and mechanistic modelling in this process |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Online resource; title from PDF title page (SpringerLink, viewed September 24, 2013) |
| Subject |
Carrier proteins.
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Pharmacology.
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Drug development.
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Drugs -- Design.
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Pharmacokinetics.
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Drugs.
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Drug Design
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Biological Transport -- physiology
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Membrane Transport Proteins -- physiology
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Pharmacokinetics
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Pharmaceutical Preparations
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Carrier Proteins
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Pharmacology
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pharmacology.
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MEDICAL -- Pharmacology.
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Pharmacokinetics
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Drugs
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Carrier proteins
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Drug development
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Drugs -- Design
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Pharmacology
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| Form |
Electronic book
|
| Author |
Sugiyama, Yuichi, editor
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Steffansen, Bente, editor
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| ISBN |
9781461482291 |
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1461482291 |
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1461482283 |
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9781461482284 |
|
