| Description |
1 online resource (xiii, 129 pages) |
| Contents |
Front Cover; Electrocardiography of Laboratory Animals; Copyright Page; Dedication; Contents; Preface; Foreword; Acknowledgements; 1 Electrocardiography in Preclinical Safety; Introduction; Regulatory Guidance versus Good Science versus Rationale Drug Development; What To Do When?; Safety Pharmacology versus Toxicology; Safety Pharmacology Studies: Core-Battery and Second-Tier Testing for Cardiotoxicity; Why Study Electrocardiography Preclinically?; Typical Cardiovascular Safety Pharmacology Designs; Rising-Dose Design; Advantages; Disadvantages; 4-Way Crossover/Latin Square Design |
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AdvantagesDisadvantages; Cardiotoxicity Endpoints in Toxicology; Regarding ECGs; Serum Enzymes; Postmortem Evaluations; The ECG and Drug Safety; 2 Principles of Electrocardiography; Recording the ECG; Cardiac Conduction and Waveform Genesis; Evaluation of the Electrocardiogram; Transmembrane Action Potentials; Evaluation of Waveforms; Mean Electrical Axis; Equipment Considerations; Cardiac Effects of Systemic Potassium and Calcium Abnormalities; Hypokalemia; Hyperkalemia; Hypocalcemia; Hypercalcemia; 3 Canine Electrocardiography; Introduction; Etiology, Pathophysiology, and Gross Pathology |
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Rhythm DiagnosisNormal Sinus Rhythm; Sinus Tachycardia; Sinus Bradycardia; Respiratory Sinus Arrhythmia; Premature Atrial Complexes; Atrial Tachycardia (AT); Atrial Fibrillation; Premature Ventricular Complexes; Accelerated Idioventricular Rhythm; Ventricular Tachycardia; Ventricular Flutter, Ventricular Fibrillation; Ventricular Asystole; Atrioventricular Block; Atrial Standstill (Silent Atrium); Sinus Node Dysfunction (Sick Sinus Syndrome, Bradycardia-Tachycardia Syndrome); Ventricular Preexcitation and Macro Reentry; 4 Handling and Restraint of Nonhuman Primates; Cynomolgus and Rhesus |
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Manual RestraintPhysical Restraint; Machine Setup and Configuration; Lead Placement; Obtaining the Tracing; Chemical Restraint; Tracing Handling and Storage; 5 Electrocardiography of Nonhuman Primates; Fundamental Principles of Electrocardiography; Basic Electrocardiographic Physiology; Cardiac Conduction System and the Electrocardiogram; Electrocardiography of Cynomolgus and Rhesus Monkeys; Introduction; Normal Sinus Rhythm; Normal Variants; Cardiac Arrhythmias; Sinoatrial Arrhythmias; Sinus Tachycardia; Sinus Arrhythmia; Sinoatrial Block and Sinus Arrest; Wandering Pacemaker |
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Sinus BradycardiaSupraventricular Arrhythmias; Atrial Premature Complexes; Atrial Tachycardia; Atrial Flutter; Atrial Fibrillation; Junctional Premature Contraction; Junctional Tachycardia; Ventricular Arrhythmias; Ventricular Premature Complexes (VPCs); Ventricular Escape Complexes; Terminology; Ventricular Tachycardia; Ventricular Fibrillation; Torsades de Pointes; Ventricular Preexcitation; Abnormalities of Impulse Conduction; Sinoatrial Standstill; First-Degree Atrioventricular Block; Second-Degree Atrioventricular Block; Third-Degree Atrioventricular Block; Bundle Branch Blocks |
| Summary |
Electrocardiography of Laboratory Animals is the only book covering electrocardiography of laboratory animals, including dogs, mini-pigs, and cynomologus monkeys. As more countries institute requirements for the care of laboratory animals in research, this publication offers an effective standard on performing and analyzing ECGs. Topics covered include safety electrocardiography, toxicology, safety pharmacology, and telemetry. Electrocardiography of Laboratory Animals will assist biological and medical researchers, veterinarians, zoologists, and students in understanding electrocardiography of various species of animals used in research. Covers safety electrocardiography of large laboratory animals. Offers comprehensive analysis of ECGs for practical laboratory use. Includes a self-evaluation section for testing of ECG reading and analysis |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
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Print version record |
| Subject |
Veterinary electrocardiography.
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Laboratory animals.
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Electrocardiography -- veterinary
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Animals, Laboratory
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Electrocardiography -- methods
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Laboratory animals
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Veterinary electrocardiography
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| Form |
Electronic book
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| Author |
Sleeper, Meg M
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| LC no. |
2013388664 |
| ISBN |
9781306167888 |
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1306167884 |
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0124159362 |
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9780124159365 |
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0124159990 |
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9780124159990 |
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