| Description |
1 online resource (464 p.) |
| Contents |
Cover -- Half Title -- Title Page -- Copyright Page -- Dedication -- Contents -- List of Figures -- 1. Introduction to Pharmacokinetics -- 1.1. Introduction -- 1.2. Pharmacokinetics and Its Related Fields -- 1.2.1. Biopharmaceutics -- 1.2.2. Pharmacokinetics -- 1.2.3. Clinical Pharmacokinetics -- 1.2.4. Pharmacodynamics -- 1.2.5. Population Pharmacokinetics -- 1.2.6. Toxicokinetics -- 1.2.7. Pharmacogenetics -- 1.3. Application of the Pharmacokinetic Principles in the Biomedical Fields -- 1.3.1. Design and Evaluation of Dosage Forms -- 1.3.2. Evaluation of Generic Drug Products |
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1.3.3. Pharmacological Testing -- 1.3.4. Toxicological Testing -- 1.3.5. Evaluation of Organ Function -- 1.3.6. Therapeutic Drug Monitoring -- 1.4. The Blood Drug Concentration-Time Profile -- 1.5. Linear and Nonlinear Pharmacokinetics -- 1.5.1. Linear Pharmacokinetics -- 1.5.2. Nonlinear Pharmacokinetics -- 1.6. Pharmacokinetic Modeling -- 1.6.1. Compartmental Modeling -- 1.6.2. Physiological Modeling -- 1.6.3. Population Pharmacokinetic Modeling -- 1.6.4. Noncompartmental Data Analysis Approach -- 1.6.5. Pharmacokinetic-Pharmacodynamic Modeling -- 1.7. Pharmacokinetic Simulations |
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1.8. Essential Graphical, Mathematical, and Statistical Fundamentals Used in Pharmacokinetics -- 1.8.1. Graphs -- 1.8.2. Curve Fitting -- 1.8.3. Determination of the Straight-Line Parameters -- 1.8.3.1. Graphical Determination of the Straight-Line Parameters -- 1.8.3.2. The Least Squares Method -- 1.8.4. Application of Basic Calculus Principles in Pharmacokinetics -- 2. Drug Pharmacokinetics Following Single Intravenous Bolus Administration: Drug Distribution -- 2.1. Introduction -- 2.2. Drug Distribution -- 2.2.1. The Rate and Extent of Drug Distribution -- 2.3. The Volume of Distribution |
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2.4. Drug Distribution after Single IV Bolus Drug Administration -- 2.5. Drug Protein Binding -- 2.5.1. Effect of Changing the Plasma Protein Binding -- 2.5.2. Determination of Plasma Protein Binding -- 2.6. Drug Partitioning to Blood Cells -- 2.7. Summary -- 3. Drug Pharmacokinetics Following Single IV Bolus Administration: Drug Clearance -- 3.1. Introduction -- 3.2. Drug Clearance -- 3.2.1. The Total Body Clearance -- 3.2.2. Physiological Approach to Drug Clearance -- 3.2.3. The Plasma Drug Concentration-Time Profile |
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3.3. Total Body Clearance and Volume of Distribution Are the Independent Pharmacokinetic Parameters -- 3.4. Determination of the Total Body Clearance -- 3.5. Summary -- 4. Drug Pharmacokinetics Following Single IV Bolus Administration: The Rate of Drug Elimination -- 4.1. Introduction -- 4.2. Drug Elimination -- 4.3. The Kinetics of the Drug Elimination Process -- 4.3.1. Zero-Order Elimination -- 4.3.1.1. The Zero-Order Elimination Rate Constant -- 4.3.1.2. The Half-Life In Zero-Order Elimination -- 4.3.2. First-Order Elimination -- 4.3.2.1. The First-Order Elimination Rate Constant |
| Summary |
This book introduces pharmacokinetic concepts to beginners to help them understand the absorption, distribution, metabolism and excretion of drugs. After a basic introduction to pharmacokinetics and its related fields, the book introduces readers to quantitative pharmacokinetic relations and the interplay between pharmacokinetic parameters |
| Notes |
Description based upon print version of record |
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4.3.2.2. Determination of the First-Order Elimination Rate Constant |
| Form |
Electronic book
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| ISBN |
9781000922011 |
|
1000922014 |
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