| Description |
1 online resource |
| Contents |
Intro -- Foreword -- References -- Preface -- Acknowledgements -- Contents -- Contributors -- 1: Principles of Modern Epidemiology and Public Health -- Introduction -- Life-Course Epidemiology -- Principles of Life-Course Research -- Development over Time -- Time and Place -- Timing -- Linked Lives -- Free Will or Agency -- Challenges for Life-Course Epidemiology -- Translational Epidemiology -- Postmodern Epidemiology -- Need for a Refocus on Postmodern Epidemiology -- Analysis Levels to be Considered in Postmodern Epidemiology -- Postmodern Epidemiology Perspective -- Final Considerations |
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Clinical Significance -- Western Blot -- Multiplex Western Blot (MWB) -- Capillary Electrophoresis (CE) and Capillary Western Blotting (CWB) -- Microfluidic Western Blotting -- Single-Cell Western Blotting -- Dot Blot -- Far-Western Blotting -- Clinical Significance -- Flow Cytometry -- Clinical Applications -- Phenotypic Characterization of Blood Cells -- Intracellular Antigen Expression -- Characterization of Antigen-Specific Responses -- Cell Cycle Analysis -- Apoptosis -- Proteomics -- Studying the Proteome -- Concluding Remarks -- References -- 3: Genomic Tools in Clinical Epidemiology |
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Introduction -- NGS in the Study of Relevant SNVs and SNPs for Epidemiological Surveillance -- Implication of NGS Technologies on the Control of SARS-CoV-2 Pandemic -- The Influence of Genomic Tools on the Management of Helicobacter pylori Infection -- General Applications of NGS Technologies in Oncology Practices -- Advances on the Pathogenesis and Treatment Knowledge of Rheumatoid Arthritis by Using NGS -- Concluding Remarks -- References -- 4: Epigenetics in Epidemiology -- Introduction -- Epigenetic Process -- Epigenetic Technology Analysis -- Overview of Bioinformatic Analysis of Epigenome |
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Epigenetic Biomarkers -- Epigenetics in Pharmacology -- Conclusions -- References -- 5: Principles of Clinical Transcriptomics and Splicing -- Introduction -- The Leap From Classic Gene Expression Studies to Transcriptomics -- General Overview of Transcriptomic Technologies -- SAGE-Derived Sequencing Technologies -- Microarrays -- RNA-seq -- Bulk Transcriptomics Profiling and Single-Cell Transcriptomics -- Splicing and Alternative Splicing -- Implications of Alternative Splicing in Clinics -- Applications of Transcriptomics in Clinical Disease -- Concluding Remarks -- References |
| Summary |
This book covers some of the most novel genetic and genomic concepts in epidemiology, such as geospatial statistics and systems biology from a clinical point of view by explaining molecular applications with accessible human studies. Featuring a comprehensive table of contents, it includes chapters from genomics and epidemiology surveillance to transcriptomics and alternative splicing principles. Across 17 well-organized chapters, this book meets attempt to explain easily to clinicians and students with basic principles of the genetics, genomics, molecular biology and its applications to epidemiology and public health. The text is distinct from other literature on the market because it covers useful genomic tools applied in epidemiology for clinicians who may not be experts in this branch of health science. Principles of Genetics and Molecular Epidemiology demystifies the idea that biomedicine is far from being applied in both epidemiology and clinical practice |
| Bibliography |
References -- 2: Molecular Tools for Modern Epidemiology: From the Concepts to Clinical Applications -- Introduction -- PCR -- Types of PCR -- Multiplex PCR -- Real-Time PCR -- Reverse Transcription PCR -- Digital PCR -- Lamp -- Principles of Karyotyping -- FISH -- Microarray -- Immunoassays -- Enzyme-Linked Immunosorbent Assay (ELISA) -- Direct ELISA (Antigen-Coated Plate, Screening Antibody) -- Indirect ELISA (Antigen-Coated Plate -- Screening Antigen/Antibody) -- Sandwich ELISA (Antibody-Coated Plate -- Screening Antigen) -- Competitive ELISA (Screening Antibody) -- New Methods |
| Notes |
Includes index |
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Online resource; title from PDF title page (SpringerLink, viewed February 8, 2022) |
| Subject |
Molecular epidemiology.
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Genetics.
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Molecular Epidemiology
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Genetics
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genetics.
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Genetics
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Molecular epidemiology
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| Form |
Electronic book
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| Author |
Gomez-Verjan, Juan Carlos, editor.
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Rivero-Segura, Nadia Alejandra, editor.
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| ISBN |
9783030896010 |
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3030896013 |
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