| Description |
1 online resource (xv, 356 pages) |
| Contents |
Introduction. The significance of heterocycles for pharmaceuticals and agrochemicals / Clemens Lamberth, Jürgen Dinges -- Neurological disorders. Tropane-based alkaloids as muscarinic antagonists for the treatment of asthma, obstructive pulmonary disease, and motion sickness / Michael L Schulte, Craig W Lindsley ; Morphinone-based opioid receptor agonist analgesics / Stephanie M Ng ; Barbituric acid-based GABA(A) receptor modulators for the treatment of sleep disorder and epilepsy and as anesthetics / Ingo Janser, Romy Janser ; Phenothiazine-based dopamine D antagonists for the treatment of schizophrenia / Cristiana A Zaharia ; Arylpiperazine-based 5-HT receptor partial agonists and 5-HT antagonists for the treatment of autism, depression, anxiety, psychosis, and schizophrenia / Irini Akritopoulou-Zanze ; Arylpiperidine-based dopamine D antagonists/5-HT antagonists for the treatment of autism, depression, schizophrenia, and bipolar disorder / Ying Wang ; Dibenzazepine-based sodium channel blockers for the treatment of neuropathic pain / Derek W Nelson -- Cardiovascular diseases. Dihydropyridine-based calcium channel blockers for the treatment of angina pectoris and hypertension / Milan Bruncko ; Tetrazole-based angiotensin II type 1 (AT) antagonists for the treatment of heart failure and congestive hypertension / Edward C Lawson, Brian C Shook, James C Lanter ; Thiazide-based diuretics for the treatment of hypertension and genitourinary disorders / Jürgen Dinges ; Tetrahydropyranone-based HMG-CoA reductase inhibitors for the treatment of arterial hypercholesterolemia / Hongyu Zhao -- Infectious diseases. Adenine-based reverse transcriptase inhibitors as anti-HIV agents / Alastair Donald ; Guanine-based nucleoside analogs as antiviral agents / Maurizio Franzini ; Penicillin and cephalosporin antibiotics / Michael Z Hoemann -- Oncology. Pyrimidine-based kinase inhibitors in cancer chemotherapy / Robert Mah ; Benzyl triazole-based aromatase inhibitors for the treatment of breast cancer / Dawn George, Stacy Van Epps -- Inflammation and gastrointestinal diseases. Acetonide-based glucocorticoids for the treatment of asthma, skin inflammation, and diseases of the eye / Kevin P Cusack, Vikram G Kalthod, Rajarathnam E Reddy, Sanjay R Chemburkar ; Benzimidazole-based H/K-ATPase inhibitors for the treatment of gastroesophageal reflux disease / Steve Swann -- Metabolic diseases. Thiazolidinedione-based insulin sensitizers: PPAR-? agonists for the treatment of type 2 diabetes / Steven Richards -- Index |
| Summary |
This volume presents important pharmaceuticals. Each of the around 20 chapters covers in a concise manner one class of heterocycles, clearly structured as follows:* Structural formulas of most important examples (market products)* Short background of history or discovery* Typical syntheses of important examples* Mode of action* Characteristic biological activity* Structure-activity relationship* Additional chemistry information (e.g. further transformations, alternative syntheses, metabolic pathways, etc.)* References. A valuable one-stop reference source for researchers in academia and industr |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Heterocyclic compounds.
|
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Pharmaceutical chemistry.
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SCIENCE -- Chemistry -- Organic.
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Heterocyclic compounds
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Pharmaceutical chemistry
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| Form |
Electronic book
|
| Author |
Lamberth, Clemens
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Dinges, Jurgen
|
| ISBN |
9783527664481 |
|
3527664483 |
|
3527333959 |
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9783527664450 |
|
3527664459 |
|
9783527333950 |
|
9781283571432 |
|
1283571439 |
|
9783527664450 |
|
