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E-book

Title Aromatase inhibitors / edited by B.J.A. Furr
Published Basel ; Boston : Birkhäuser, ©2006

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Description 1 online resource (ix, 182 pages) : illustrations
Series Milestones in drug therapy
Milestones in drug therapy.
Contents Background and development of aromatase inhibitors -- Aromatase inhibitors and models for breast cancer -- Clinical pharmacology of aromatase inhibitors -- Clinical studies with exemestane -- Clinical studies with letrozole -- Clinical studies with anastrozole -- The third-generation aromatase inhibitors: a clinical overview -- Lessons from the ArKO mouse -- Possible additional therapeutic uses of aromatase inhibitors
Summary Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase). Whereas the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy
Bibliography Includes bibliographical references and index
Notes English
Subject Breast -- Cancer -- Chemotherapy
Aromatase -- Inhibitors -- Therapeutic use
Toxicology.
Breast Neoplasms -- drug therapy
Aromatase Inhibitors -- therapeutic use
Toxicology
toxicology.
MEDICAL -- Oncology.
HEALTH & FITNESS -- Diseases -- Cancer.
Aromatase -- Inhibitors -- Therapeutic use.
Breast Neoplasms -- drug therapy.
Aromatase Inhibitors -- therapeutic use.
Breast -- Cancer -- Chemotherapy.
Biomédecine.
Sciences de la vie.
Breast -- Cancer -- Chemotherapy
Form Electronic book
Author Furr, B. J. A
LC no. 2005057021
ISBN 9783764371999
3764371994
3764374187
9783764374181
6610461635
9786610461639
1280461632
9781280461637