| Description |
1 online resource (210 pages) |
| Series |
Progress in the Chemistry of Organic Natural Products ; v. 115 |
|
Progress in the chemistry of organic natural products (2011) ; 115.
|
| Contents |
Total Synthesis of Decanolides (Nonanolides) with a Special Focus on Olefin Metathesis -- From Plant to Patient: Thapsigargin -- Antileishmanial Activity of Lignans and Neolignans -- Cryptolepine as a Lead to new Antiprotozoal Agents -- Biologically Active Constituents from Plants of the Genus Xanthium |
| Summary |
This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca2+ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer |
| Notes |
Print version record |
| Subject |
Chemistry, Organic.
|
|
Pharmaceutical chemistry.
|
|
Clinical biochemistry.
|
|
organic chemistry.
|
|
Chemistry, Organic
|
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Clinical biochemistry
|
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Pharmaceutical chemistry
|
| Form |
Electronic book
|
| Author |
Kinghorn, A. Douglas.
|
|
Falk, Heinz, 1939-
|
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Gibbons, Simon (Professor of medicinal phytochemistry)
|
|
Asakawa, Yoshinori.
|
|
Liu, Ji-Kai
|
|
Dirsch, Verena M
|
| ISBN |
9783030648534 |
|
3030648532 |
|
