| Description |
1 online resource |
| Series |
Cancer drug discovery and development ; 72 |
|
Cancer drug discovery and development ; 72.
|
| Contents |
Repair of DNA Interstrand Cross-links Produced by Cancer Chemotherapeutic Drugs / Anderson T. Wang, Peter J. McHugh -- DNA-PK, a Pharmacological Target in Cancer Chemotherapy and Radiotherapy? / Bernard Salles D.V.M., Ph. D. -- Growth Factor Receptor Signaling, DNA Damage Response, and Cancer Cell Susceptibility to Chemotherapy and Relapses / Moulay Alaoui-Jamali, Amine Saad, Gerald Batist -- The Relationship Between DNA-Repair Genes, Cellular Radiosensitivity, and the Response of Tumors and Normal Tissues to Radiotherapy / David Murray, Matthew Parliament -- Important Roles of ERCC1 in DNA Repair and Targeted Therapy / Jennifer J. Hu, Joseph de la Garza -- The Role of BRCA1 and BRCA2 in Anticancer Drug Therapy / Andrew Y. Shuen, Jorge S. Reis-Filho -- DNA-PK in CLL Chemotherapy / L. Amrein, D. Davidson, R. Aloyz, L. Panasci -- Poly(ADP) Ribose Polymerase at the Interface of DNA Damage Signaling and DNA Repair / Jana Krietsch, Michèle Rouleau, Michel Lebel -- Cellular Protection Against the Antitumor Drug Bleomycin / Dindial Ramotar Ph. D., Mustapha Aouida Ph. D. -- ATR as a Therapeutic Target / Fiona K. Middleton, Nicola J. Curtin -- Telomeres, Telomerase, and DNA Damage Response in Cancer Therapy / Raina A. Tamakawa, Helen B. Fleisig -- RAD51 Is a Key Protein of DNA Repair and Homologous Recombination in Humans / Alexander V. Mazin Ph. D., Olga M. Mazina |
| Summary |
This book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin. The DNA repair genes discussed include those involved in BRCA/Rad51-related homologous recombinational repair, DNA-PK related nonhomologous endjoining and the nucleotide excision repair gene, ERCC1. Moreover, the role of regulatory genes such as PARP, ATR, telomerase, growth factor receptors and downstream kinase signalling is examined |
| Analysis |
Medicine |
|
Oncology |
|
Biomedicine |
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Cancer Research |
|
Molecular Medicine |
|
geneeskunde |
|
biomedische wetenschappen |
|
neoplasms |
|
Medicine (General) |
|
Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
| Subject |
DNA repair.
|
|
Cancer -- Chemotherapy.
|
|
Cancer -- Genetic aspects.
|
|
DNA Repair
|
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Neoplasms -- genetics
|
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Neoplasms -- drug therapy
|
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Antineoplastic Agents -- therapeutic use
|
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HEALTH & FITNESS -- Diseases -- Cancer.
|
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MEDICAL -- Oncology.
|
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Médecine.
|
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Cancer -- Chemotherapy
|
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Cancer -- Genetic aspects
|
|
DNA repair
|
| Form |
Electronic book
|
| Author |
Panasci, Lawrence C.
|
|
Aloyz, Raquel.
|
|
Alaoui-Jamali, Moulay A.
|
| ISBN |
9781461447412 |
|
1461447410 |
|
1461447402 |
|
9781461447405 |
|
