Title Small molecules in oncology / Uwe M. Martens, editor

Edition Second edition Published Heidelberg : Springer, [2014] ©2014

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Description 1 online resource (xvi, 238 pages) : illustrations Series Recent results in cancer research ; volume 201 Recent results in cancer research ; v. 201. Contents Imatinib Mesylate -- Dasatinib -- Nilotinib -- Bosutinib: A Novel Second-Generation Tyrosine Kinase Inhibitor -- Ponatinib: A Third-Generation Inhibitor for the Treatment of CML -- Erlotinib -- Lapatinib -- Sorafenib: Targeting Multiple Tyrosine Kinases in Cancer -- Sunitinib in the Treatment of Advanced Solid Tumors -- Regorafenib -- Crizotinib -- Cabozantinib: A MET, RET, and VEGFR2 Tyrosine Kinase Inhibitor -- Vemurafenib -- Dabrafenib -- Trametinib -- Ruxolitinib -- Ibrutinib -- Decitabine -- 5-Azacytidine/5-Azacitidine -- Bortezomib -- Lenalidomide -- Pomalidomide -- Everolimus -- Temsirolimus -- Vismodegib Summary Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the progress being made will result in significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book, written by acknowledged experts, discusses in detail the most recent developments in targeted cancer therapy using small molecules. A wide range of small molecules is covered, including, in addition to tyrosine kinase inhibitors, mTOR, proteasome, and multikinase inhibitors, among others. For each molecule, aspects such as chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed Bibliography Includes bibliographical references Notes Print version record Subject Cancer -- Molecular aspects. Antineoplastic agents. Cancer -- Treatment. Antimitotic agents. Neoplasms -- drug therapy Antineoplastic Agents -- therapeutic use Azacitidine -- therapeutic use Protein Kinase Inhibitors -- therapeutic use Antineoplastic Agents Antimitotic Agents HEALTH & FITNESS -- Diseases -- General. MEDICAL -- Clinical Medicine. MEDICAL -- Diseases. MEDICAL -- Evidence-Based Medicine. MEDICAL -- Internal Medicine. Médecine. Antimitotic agents Antineoplastic agents Cancer -- Molecular aspects Cancer -- Treatment Cytostatikum Kleines Molekül Form Electronic book Author Martens, Uwe M., editor ISBN 9783642544903 3642544908 3642544894 9783642544897

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