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Book Cover
Author Kaur, Prabhjot (Associate professor of pathology), author.

Title Chronic lymphocytic leukemia : pathobiology, B cell receptors, novel mutations, clonal evolution / Prabhjot Kaur
Published Cham : Humana Press, 2018


Description 1 online resource
Series Molecular and translational medicine
Molecular and translational medicine.
Contents Intro; Preface; Contents; About the Author; Chapter 1: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Introduction-Definition, Diagnosis, Cell of Origin; Epidemiology; Historical Perspective; The CLL Story: How Did It All Begin (The Old and the New Perspectives); Classification Systems from the 1960s to 2016; Cell of Origin; Clinical Features; Morphology and Phenotype; FMC7 and Its Role in CLL Phenotyping; Monoclonal B-Cell Lymphocytosis (MBL); Small Lymphocytic Lymphoma (SLL); Progression and Transformation; Treatment; CD20 and Therapeutic Implications
CD19 and Therapeutic ImplicationsMinimal Residual Disease (MRD); References; Chapter 2: Prognostic Indicators in CLL: Clinical, Cytogenetics, Novel Mutations, MicroRNAs, Hierarchal Classification; Lymphocyte Doubling Time (LDT); Serologic Indicators of Tumor Burden in CLL; Cell Surface Receptors as Prognostic Markers; Chromosomal Aberrations in CLL; Complex Karyotype and Translocations in CLL; B-Cell Receptor (BCR) Mutation Status; Novel Mutations in CLL; MicroRNAs; Hierarchal Classification; References; Chapter 3: B-Cell Receptors; Introduction; B-Cell Receptor
BCR in CLL: Ontogeny and PrognosisBCR Signaling in Normal B Cells; BCR Signaling in CLL; BCR Signaling: Therapeutic Implications; References; Chapter 4: Microenvironment; Introduction; The CLL Microenvironment; CD49d in Biology, Prognosis, and Therapeutics; Therapeutics; References; Chapter 5: Clonal Evolution: Driver/Passenger Mutation Model in CLL; Proliferative Activity; Intratumoral Heterogeneity; Clonal Evolution: Driver/Passenger Mutation Model in CLL; Clonal Evolution: The Epigenetic Evidence; Clonal Evolution: The Genetic Evidence; Clonal Evolution: Impact on Treatment
Summary This text provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for pathologists and clinical hematologists/oncologists with an interest in chronic lymphocytic leukemia. This book is designed to provide a concise yet comprehensive summary of the traditional and new definitions, prognostic markers, the pathobiology and newer hierarchal classification based on molecular genetics/chromosomal abnormalities. It will include the most up-to-date scientific and clinical information and bring together subject matter that is usually covered separately in various specialties of hematopathology, molecular pathology, basic science and immunology. The book is written in an easy to comprehend format with emphasis on the science and illustrations to explain the same. It is therefore intended to intrigue, the junior resident and the senior pathologists/clinical oncologists and anyone who would like to keep up with this rapidly growing field
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (EBSCO, viewed February 19, 2018)
Subject Lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell -- diagnosis
Clonal Evolution
Leukemia, Lymphocytic, Chronic, B-Cell -- therapy
Leukemia, Lymphoid
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Lymphocytic leukemia
Form Electronic book
ISBN 9783319706030