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Title Immunopathogenetic aspects of disease induced by Helminth parasites / volume editor, David O. Freedman
Published Basel ; New York : Karger, ©1997


Description 1 online resource (xii, 235 pages) : illustrations
Series Chemical immunology ; vol. 66
Chemical immunology ; vol. 66.
Contents The basis of IgE responses to specific antigenic determinants in helminthiasis -- Immunopathology of onchocerciasis: a role for eosinophils in onchocercal dermatitis and keratitis -- Enteric helminth infection: immunopathology and resistance during intestinal nematode infection -- Pathogenesis of human hookworm infection: insights from 'new' zoonosis -- Human toxocariasis and the visceral lava migrans syndrome: correlative immunopathology -- Lymphatic filariasis -- Immunologic basis of disease and disease regulation in schistosomiasis -- Immunopathology of echinococcosis --Taenia solium cysticercosis: host-parasite interactions and the immune response
Summary Just as the magnitude of the growth and developmental problems attributable to human helminthiasis are being fully realized, we are able for the first time to describe defined immune responses giving rise to the pathological lesions seen. On the basis of the different sets of cytokines produced by CD4+ T cells, these responses can be classified according to the Th1/Th2/Th0 paradigm. Deleterious inflammatory responses to metazoan parasites appear to be consistently associated with a highly polarized Th2 cytokine profile. Thus, host-parasite models involving specific enteric and tissue helminths have provided seminal data on immunoregulatory and immunopathogenetic responses that are more broadly generalizable to the entire Th1/Th2 paradigm. The first three articles in this volume present an overview of recent advances in the understanding of the induction of IgE, eosinophilic, and cytokine regulatory responses to helminthic infection. Subsequent articles comprehensively review immunopathogenetic aspects of schistosomiasis, hookworm infection, echinococcosis, lymphatic filariasis, onchocerciasis, toxocariasis, and cysticercosis, and, at the same time, emphasize key directions and priorities. Conclusions from animal models of infection are set in the context of human disease wherever possible. For all immunologists with an interest in cytokine biology and for those interested in the biology of tropical infectious diseases this volume is essential reading
Bibliography Includes bibliographical references and index
Notes Current copyright fee: GBP36.40 24\0. Uk
Print version record
Subject Helminthiasis -- Immunological aspects
Helminthiasis -- immunology
Helminthiasis -- pathology
Helminthiasis -- Immunological aspects
Genre/Form Aufsatzsammlung.
Form Electronic book
Author Freedman, David O
S. Karger (Firm)
ISBN 9783318002249