| Description |
1 online resource (xxi, 1075 pages) : illustrations (some color) |
| Contents |
I. Introduction -- II. Animal Models -- III. Comparative Models of Aging and Age-Related Diseases |
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Historical development of animal models of aging / Richard L. Sprott and Steven N. Austad -- Species selection in comparative studies of aging and antiaging research / João Pedro de Magalhães -- Principles of animal use for gerontological research / Richard A. Miller -- from primary cultures to the aging organism: lessons from human T lymphocytes / Rita B. Effros -- Models of systems failure in aging / Leonid A. Gavrilov and Natalia S. Gavrilova -- Major issues in ethics of aging research / Michael D. Smith -- Ethical aspects of research involving elderly persons / Paul S. Mueller and C. Christopher Hook -- SAGE KE and other online sources related to aging / Evelyn Strauss and R. John Davenport -- Proteomics in aging research / Christian Schöneich -- Application of high-throughput technologies to aging-related research / Matt Kaeberlein -- Models of Alzheimer's disease / Harry LeVine III and Lary C. Walker -- Age-related hippocampal dysfunction: early Alzheimer's disease vs. normal aging / Scott A. Small -- Epidemiology in aging research / Hermann Brenner and Volker Arndt |
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Statistical issues for longevity studies in animal models / Chenxi Wang [and others] -- Models for the study of infection in populations / John R. Williams -- Estimation of the rate of production of oxygen radicals by mitochondria / Alberto Sanz and Gustavo Barja -- Telomeres and aging in the yeast model system / Kurt W. Runge -- Longevity and aging in budding yeast / Matt Kaeberlein -- From yeast Methuselah genes to evolutionary medicine / Paolo Fabrizio and Valter D. Longo -- Strongyloides ratti: a nematode wth extraordinary plasticity in aging / Michael P. Gardner, David Gems, and Mark E. Viney -- Insect models for the study of aging / Klaus-Günter Collatz -- Drosophila models of aging / Satomi Miwa and Alan Cohen -- Models of aging in honeybee workers / Gro v. Amdam and Olav Rueppell -- Ants as naturally long-lived insect models for aging / Joel D. Parker and Karen M. Parker -- Gene expression and the extended longevity phenotypes of Drosophila melanogaster / Robert Arking -- Annual fish as a genetic model for aging / Pudur Jagadeeswaran |
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The use of mature zebrafish (Danio rerio) as a model for human aging and disease / Evan T. Keller, Jill M. Keller, and Gavin Gillespie -- Zebrafish as aging models / Shuji Kishi -- Telomeres in aging: birds / Susan E. Swanberg and Mary E. Delany -- Domestic and wild bird models for the study of aging / Donna J. Holmes and Mary Ann Ottinger -- A transgenic mini rat strain as a tool for studying aging and calorie restriction / Isao Shimokawa -- Rat models of age-related cognitive decline / Jennifer L. Bizon and Michelle M. Nicolle -- Aged rodents for biogerontology research / Nancy L. Nadon -- Life extension in the dwarf mouse / Andrzej Bartke -- The canine model of human brain aging: cognition, behavior, and neuropathology / P. Dwight Tapp and Christina T. Siwak -- Bats as a novel model for aging research / Anja K. Brunet-Rossinni and Rocco E. Rossinni -- Memory in the aging hippocampus: what can place cells tell us? / Iain A. Wilson -- The rhesus macaque as a model of human aging and age-related disease / Mary Ann Ottinger [and others] |
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Nonhuman primates as a models for reproductive aging and human infertility / Barry D. Bavister and Carol A. Brenner -- Neurobiology fo the aging brain / Carlo Bertoni-Freddari [and others] -- Mitochondrial DNA and aging / Mikhail Alexeyev, Susan P. LeDoux, and Glenn L. Wilson -- Models for apoptosis: from newborn to adult / Christiane Charriaut-Marlangue and Sylvain Renolleau -- Age-related changes in hormones and their receptors in animal models of female reproductive senescence / Jacqueline A. Maffucci and Andrea C. Gore -- Models of chaperones in aging / Jens Krøll and J.O. Nehlin -- Therapeutic potential of stem cells in aging-related diseases / Shannon Whirledge, Kirk C. Lo, and Dolores J. Lamb -- Nuclear transfer and cloning: preservation or expansion of proliferative lifespan? / Keith E. Latham -- Human models of longevity / Thomas Perls -- Computational models of mitochondrial DNA in aging / David C. Samuels -- Mouse models of accelerated aging / Jan Vijg and Paul Hasty |
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Models, definitions, and criteria of frailty / David B. Hogan -- Fertility and aging men: an introduction to the male biological clock / Peter N. Schlegel [and others] -- Benign prostatic hyperplasia / Peter Celec -- Murine models of infectious diseases in the aged / Kevin P. High -- Studying infection in the elderly: physiopathology, clinical symptoms and causative agents of pneumonia / Jean-Paul Janssens -- Diabetes and aging / Tamas Fülöp [and others] -- Diabetes as a model of premature aging / Arshag D. Mooradian -- Frailty as a model of aging / Jeremy d. Walston -- Osteoporosis and cardiovascular disease in the elderly / Samy I. McFarlane, John Nicasio, and Ranganath Muniyappa -- Depression in older patients / Kiran Rabheru -- The aging human lung: age-associated changes in structure and function / Keith C. Meyer -- Iceland as a model for human aging / Adalsteinn Gudmundsson and Pálmi V. Jónsson |
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Behavior and personality in the study of successful aging / Judith Corr and Loraine Tarou -- Andropause / Rabih Hijazi and Glenn R. Cunningham -- Aging and the perceptual organization of sounds: a change of scene? / Claude Alain, Benjamin J. Dyson, and Joel S. Snyder -- Models of immune function in aging / Christopher a. Jolly and Zhun Xu -- Human T cell clones in long-term culture as models for the impact of chronic antigenic stress in aging / Graham Pawelec [and others] -- Age-related changes in the human retina / Carlo Cavallotti and Nicola Pescosolido -- Models of age-related vision problems / J. Fielding Hejtmancik, Mark Kantorow, and Takeshi Iwata -- Health, functional and therapeutic implications of obesity in aging / R. Lee Kennedy and E.Y.H. Khoo -- Age and joints / Klaus Bobacz and Ilse-Gerlinde Sunk -- Sleep quality in the elderly / Ragnar Asplund -- Atherogenesis and aging / Cam Patterson |
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Managing menopausal symptoms / Mary Ellen rousseau -- Psychological aging: a contextual view / Hans-Werner Wahl and Frieder R. Lang -- Nutrients and aging / Lawrence J. Whalley -- Methods for studying hearing impairment and auditory problems of the aged / Robert D. Frisina and D. Robert Frisina -- A mdoel for understanding the pathomechanics of osteoarthritis in aging / Thomas P. Andriacchi and Annegret Mündermann -- Aging and cardiovascular angiogenesis models / Andrew Chin [and others] -- Models for the study of stroke / Thiruma V. Arumugam and Mark P. Mattson -- Werner syndrome as a model of human agiing / Raymond J. Monnat, Jr. -- Models of sarcopenia / Alfred L. Fisher -- Aging of human skin / Paolo U. Giacomoni -- Models of hypertension in aging / Jane F. Reckelhoff [and others] |
| Summary |
This Handbook is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. *Utilizes a multidisciplinary approach *Shows tricks and approaches not available in primary publications *First volume of its kind to combine both methods of study for human aging and animal models *Over 200 illustrations |
| Analysis |
verouderen |
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aging |
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wiskundige modellen |
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mathematical models |
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dieren |
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animals |
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genexpressie |
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gene expression |
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ziekte van alzheimer |
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alzheimer's disease |
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humane ziekten |
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human diseases |
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moleculaire biologie |
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molecular biology |
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Animal Development and Life Cycle |
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Mathematical Models, Simulation Models |
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Dierlijke ontwikkeling en levenscyclus |
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Wiskundige modellen, simulatiemodellen |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Aging -- Handbooks, manuals, etc
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Aging.
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Biological models.
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Aging
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Models, Animal
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Models, Biological
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MEDICAL -- Nursing -- Gerontology.
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FAMILY & RELATIONSHIPS -- Aging.
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Biological models.
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Aging.
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Veroudering (biologie, psychologie)
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Mensen.
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Dierproeven.
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Biomedisch onderzoek.
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| Genre/Form |
Handbooks and manuals.
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Handbooks and manuals.
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Guides et manuels.
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| Form |
Electronic book
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| Author |
Conn, P. Michael
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| ISBN |
9780123693914 |
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0123693918 |
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0080460062 |
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9780080460062 |
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