| Description |
1 online resource (xvi, 563 pages) : color illustrations |
| Series |
Methods in molecular biology, 1940-6029 ; v. 1303 |
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Methods in molecular biology (Clifton, N.J.) ; v. 1303. 1064-3745
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| Contents |
Alzheimer's as a systems-level disease involving the interplay of multiple cellular networks / Juan I. Castrillo and Stephen G. Oliver -- Application of systems theory in longitudinal studies on the origin and progression of Alzheimer's disease / Simone Lista [and others] -- APP proteolytic system and its interactions with dynamic networks in Alzheimer's disease / Sally Hunter, Steven Martin, and Carol Brayne -- Effects of mild and severe oxidative stress on BACE1 expression and APP amyloidogenic processing / Jiangli Tan, Qiao-Xin Li, and Genevieve Evin -- Advanced assay monitoring APP-carboxyl-terminal fragments as markers of APP processing in Alzheimer disease mouse models / Ana García-Osta and Mar Cuadrado-Tejedor -- Optical super-resolution imaging of [beta]-amyloid aggregation in vitro and in vivo : method and techniques / Dorothea Pinotsi, Gabriele S. Kaminski Schierle, and Clemens F. Kaminski -- Protocols for monitoring the development of Tau pathology in Alzheimer's disease / Alberto Rábano [and others] -- LC3-II tagging and western blotting for monitoring autophagic activity in mammalian cells / Anne Streeter, Fiona M. Menzies, and David C. Rubinsztein -- Advanced mitochondrial respiration assay for evaluation of mitochondrial dysfunction in Alzheimer's disease / Amandine Grimm, Karen Schmitt, and Anne Eckert -- Analysis of microglial proliferation in Alzheimer's disease / Diego Gomez-Nicola and V. Hugh Perry -- Yeast as a model for Alzheimer's disease : latest studies and advanced strategies / Mathias Verduyckt [and others] -- Yeast as a model for studies on A[beta] aggregation toxicity in Alzheimer's disease, autophagic responses, and drug screening / Afsaneh Porzoor and Ian Macreadie -- Drosophila melanogaster as a model for studies on the early stages of Alzheimer's disease / Jung Yeon Lim, Stanislav Ott, and Damian C. Crowther -- Chronic mild stress assay leading to early onset and propagation of Alzheimer's disease phenotype in mouse models / Mar Cuadrado-Tejedor and Ana García-Osta -- Gene expression studies on human trisomy 21 iPSCs and neurons : towards mechanisms underlying Down's syndrome and early Alzheimer's disease-like pathologies / Jason P. Weick, Huining Kang, George F. Bonadurer III, and Anita Bhattacharyya -- Cortical differentiation of human pluripotent cells for in vitro modeling of Alzheimer's disease / Nathalie G. Saurat, Frederick J. Livesey, and Steven Moore -- Next generation sequencing in Alzheimer's disease / Lars Bertram -- Pooled-DNA sequencing for elucidating new genomic risk factors, rare variants underlying Alzheimer's disease / Sheng Chih Jin, Bruno A. Benitez, Yuetiva Deming, and Carlos Cruchaga -- New genome-wide methods for elucidation of candidate copy number variations (CNVs) contributing to Alzheimer's disease heritability / Kinga Szigeti -- RNA-sequencing to elucidate early patterns of dysregulation underlying the onset of Alzheimer's disease / Bei Jun Chen, James D. Mills, Caroline Janitz, and Michael Janitz -- Systems biology approaches to the study of biological networks underlying Alzheimer's disease : role of miRNAs / Wera Roth, David Hecker, and Eugenio Fava -- Emerging role of metalloproteomics in Alzheimer's disease research / Dominic J. Hare, Alan Rembach, and Blaine R. Roberts -- Redox proteomics in human biofluids : sample preparation, separation and immunochemical tagging for analysis of protein oxidation / Fabio Di Domenico, Marzia Perluigi, and D. Allan Butterfield -- Advanced shotgun lipidomics for characterization of altered lipid patterns in neurodegenerative diseases and brain injury / Miao Wang and Xianlin Han -- AlzPathway, an updated map of curated signaling pathways : towards deciphering Alzheimer's disease pathogenesis / Soichi Ogishima [and others] -- Computational network biology approach to uncover novel genes related to Alzheimer's disease / Andreas Zanzoni -- Network approaches to the understanding of Alzheimer's disease : from model organisms to humans / Justin Yerbury, Dan Bean, and Giorgio Favrin -- Characterization of genetic networks associated with Alzheimer's disease / Bin Zhang, Linh Tran, Valur Emilsson, and Jun Zhu -- Network-based analysis for uncovering mechanisms underlying Alzheimer's disease / Masataka Kikuchi [and others] -- SDREM method for reconstructing signaling and regulatory response networks : applications for studying disease progression / Anthony Gitter and Ziv Bar-Joseph -- Advanced neuroimaging methods towards characterization of early stages of Alzheimer's disease / Jorge Sepulcre and Joseph C. Masdeu -- Plasma proteomics biomarkers in Alzheimer's disease : latest advances and challenges / Robert Perneczky and Liang-Hao Guo -- Practical guide for exploring opportunities of repurposing drugs for CNS diseases in systems biology / Hongkang Mei [and others] |
| Summary |
"Alzheimer's disease (AD) and many other neurodegenerative disorders are multifactorial in nature, involving a combination of genomic, epigenomic, network dynamic and environmental factors. A proper investigation requires new integrative Systems Biology approaches, at both the experimental and computational level. The interplay of disease mechanisms and homeostatic networks will underlie the time of onset and rate of progression of the disease. This book addresses such an integrated approach to AD. It aims to present Systems Biology, including both experimental and computational approaches, as a new strategy for the study of AD and other multifactorial diseases, with the hope that the results will translate into more effective diagnosis and treatment, as well as improved public health policies. Written for the highly successful Methods in Molecular Biology series, practical and cutting-edge, Systems Biology of Alzheimer's Disease is intended for post-graduate students, post-doctoral researchers and experts in different fields with an interest in comprehensive Systems Biology strategies applicable to AD and other complex multifactorial diseases (including other neurodegenerative diseases and cancers). This book aims to complement other excellent volumes and monographs on AD that cover fundamental, physiological or medical aspects of the disease."--Back cover |
| Analysis |
biomedische wetenschappen |
|
biomedicine |
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neurowetenschap |
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neuroscience |
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Medicine (General) |
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Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Alzheimer's disease.
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Systems biology.
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Alzheimer Disease -- physiopathology
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Systems Biology -- methods
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Alzheimer Disease
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Systems Biology
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Neurosciences.
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Medical -- Neuroscience.
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Alzheimer's disease
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Systems biology
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| Form |
Electronic book
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| Author |
Castrillo, Juan I., editor
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Oliver, S. G. (Stephen George), 1949- editor.
|
| ISBN |
9781493926275 |
|
1493926276 |
|
1493926268 |
|
9781493926268 |
|
