Title BACE : Lead Target for Orchestrated Therapy of Alzheimer's Disease / edited by Varghese John

Published Hoboken, N.J. : John Wiley & Sons, ©2010

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Description 1 online resource (1 electronic resource (xvi, 250 pages, 16 unnumbered pages of plates)) : illustrations (some color) Contents BACE : APP processing, and signal transduction in Alzheimer's disease / Dale E. Bredesen and Edward H. Koo -- Identification of BACE as a target in Alzheimer's disease / Robert L. Heinrikson and Sukanto Sinha -- BACE biological assays / Alfredo G. Tomasselli and Michael J. Bienkowski -- Peptidic, peptidomimetic, and HTS based BACE inhibitors / James P. Beck and Dustin J. Mergott -- Fragment-based approaches for identification of BACE inhibitors / Andreas Kuglstatter and Michael Hennig -- Structure-based drug design of BACE inhibitors : technical and practical aspects of preparation, 3-dimensional structure, and computational analysis / Felix F. Vajdos, Veerabahu Shanmugasundaram, and Alfredo G. Tomasselli -- Pharmacological models for preclinical testing : from mouse to dog to non-human primates / Jason L. Eriksen, Michael Paul Murphy, and Elizabeth Head -- Adsorption, distribution, metabolism, excretion (ADME), efficacy, and toxicology for BACE inhibitors / Ishrut Hussain and Emmanuel Demont -- Clinical trials for disease-modifying drugs such as BACE inhibitors / Henry H. Hsu -- Future strategies for development of novel BACE inhibitors : anti-APP B-site antibody and APP binding small molecule approaches for Alzheimer's disease / Beka Solomon [and others] Summary BACE inhibitors and their use in the treatment of Alzheimer's Disease. BACE (ß-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and Bibliography Includes bibliographical references and index Notes English Print version record Subject Alzheimer's disease -- Chemotherapy Aspartic proteinases -- Inhibitors -- Therapeutic use Amyloid beta-protein precursor. Alzheimer Disease -- drug therapy Amyloid Precursor Protein Secretases -- pharmacology Amyloid Precursor Protein Secretases -- therapeutic use Amyloid beta-Protein Precursor MEDICAL -- Geriatrics. MEDICAL -- Nursing -- Gerontology. Alzheimer's disease -- Chemotherapy Amyloid beta-protein precursor Form Electronic book Author John, Varghese, 1958- LC no. 2009037093 ISBN 9780470594087 047059408X 9780470594070 0470594071 128249175X 9781282491755 047029342X 9780470293423 9786612491757 6612491752

Other Titles Beta-site APP Cleaving Enzyme

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