| Description |
1 online resource : illustrations |
| Contents |
Front Cover; Arousal in Neurological and Psychiatric Diseases; Copyright; Dedication; Contents; Contributors; Preface; Acknowledgments; Chapter 1: Arousal and normal conscious cognition; Introduction; Arousal and consciousness; Electroencephalogram; Wakefulness; EEG correlates of wakefulness and arousal; Wakefulness-promoting neuronal networks; NREM sleep; NREM sleep-promoting system; REM sleep; Neural systems that promote the generation of REM sleep; Drug-induced loss of consciousness: General anesthesia; Drug-induced alteration of consciousness |
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Ketamine, a pharmacological model of psychosisDissociative state induced by atropine and scopolamine; Conclusions; Acknowledgments; References; Chapter 2: Physiology of arousal; Introduction; Arousal and the maintenance of arousal; Gamma activity in the RAS; Two calcium channels; Two intracellular pathways; Cortical manifestations; Bottom-up gamma; Posture and locomotion; The mesencephalic locomotor region; Optogenetics; Clinical implications; Future directions; Acknowledgments; References; Further reading; Chapter 3: Schizophrenia and arousal; Introduction; Symptoms; Etiology |
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EEG, reflexes, and P50 potentialTreatment; Neuronal calcium sensor protein 1 in schizophrenia; Clinical implications; References; Chapter 4: Bipolar disorder, depression, and arousal; Bipolar disorder; Symptoms; Etiology; EEG, reflexes, and P50 potential; Neuronal calcium sensor protein 1; Treatment; Major depression; Symptoms; Etiology; EEG, reflexes and P50 potential; Treatment; Hypofrontality; Acknowledgments; References; Chapter 5: Posttraumatic stress and anxiety, the role of arousal; Introduction; Symptoms; Etiology; The stress-response; The anxiety disorders |
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EEG, reflexes and P50 potentialTreatment; References; Chapter 6: Autism and arousal; Introduction; Background; The frontal cortex; The amygdala; The nucleus accumbens; Arousal and attention; Sensory modulation; Autism and the P50 potential; Autism and sleep; Treatments; References; Chapter 7: Arousal and drug abuse; Introduction; Thalamocortical dysrhythmia, a potential mechanism for drug-seeking behavior; Symptoms and etiology of arousal alterations mediated by stimulants; Symptoms and etiology of arousal alterations mediated by sedative-hypnotics and anesthetics |
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Clinical manifestations of arousal alterations by drug abuse and its social and economic impactConcluding remarks; Acknowledgments; References; Further readingg; Chapter 8: Arousal and the Alzheimer disease; Introduction; Symptoms; Etiology; EEG, reflexes, and P50 potential; Treatment; Mechanisms; Cortical mechanisms; References; Chapter 9: Deep brain stimulation of the pedunculopontine tegmental nucleus and arousal in Parkinson's disease; Introduction; Patients and methods; Patients; Methods; Polysomnographic recordings; Sleep analysis; Frequency analysis; Connectivity analysis |
| Summary |
Arousal in Neurological and Psychiatric Diseases focuses on the dysregulation of arousal found in many neurological and psychiatric disorders. Chapters describe the physiology of each process, how it presents in each disorder, and the most appropriate treatment(s). The book also imparts the understanding of the RAS as a system that not only modulates waking, but also survival mechanisms, such as fight vs. flight responses and other reflexes. This book helps neuroscientists, sleep researchers, neurologists and psychiatrists understand the basic mechanisms that modulate arousal in health and disease. In addition, it promotes therapies that can alter the severity and manifestation of multiple disorders. Provides a comprehensive overview of the basic mechanisms behind dysregulation of arousal in neurological and psychiatric disorders; Describes, in detail, the function of the Reticular Activating System with respect to higher functions, motor control and the intertwining of arousal and motor disorders; Covers multiple neurological disorders, including epilepsy, Alzheimer's disease, Parkinson's disease and autism |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (EBSCO, viewed June 24, 2019) |
| Subject |
Arousal (Physiology)
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Reticular formation.
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Arousal
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Deep Brain Stimulation
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Nervous System Diseases -- therapy
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Reticular Formation
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MEDICAL -- Physiology.
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SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
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Arousal (Physiology)
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Reticular formation
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| Form |
Electronic book
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| Author |
Garcia-Rill, Edgar, editor.
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| ISBN |
9780128179932 |
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0128179937 |
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0128179929 |
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9780128179925 |
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