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Book Cover
E-book

Title Deciphering drug targets for Alzheimer's disease / Dileep Kumar, Vaishali M. Patil, Dee Wu, Nanasaheb Thorat, editors
Published Singapore : Springer, [2023]

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Description 1 online resource (378 pages) : illustrations (black and white, and color)
Contents Chapter 1.Deciphering New Drug Targets in Alzheimers Disease -- Chapter 2. Novel Therapeutic Targets for Treating Alzheimers Disease -- Chapter 3. Modified Investigation Tools and Techniques Useful in Alzheimers Disease Research -- Chapter 4. Dual Specificity Tyrosine Phosphorylation Regulated Kinase1A (DYRK1A) Inhibitors: The Quest for a Disease-Modifying Treatment for Alzheimers Disease -- Chapter 5. -secretase as a primary drug target of Alzheimer disease: Function, Structure, and Inhibition -- Chapter 6. Endocrine Receptors: The Potential Therapeutic Targets for Alzheimers -- Chapter 7. Calcium Channels as a Potential Therapeutic Target for Alzheimers Disease -- Chapter 8. Traversing Through the Trajectory of Pathogenic Astrocytes in Alzheimers Disease -- Chapter 9. Targeting Mitochondrial Dynamics as a Restorative Approach in the Treatment of Alzheimers Disease -- Chapter 10. Epigenetic Therapy for Alzheimers Disease -- Chapter 11. Exploring the Diverse Roles of GSK-3 Kinase in Alzheimers Disease -- Chapter 12. Role of Target Fishing in Discovery of Novel Anti-Alzheimers Agents: In Silico Applications -- Chapter 13. Multi-Target Directed Ligand Approach in Anti-Alzheimers Drug Discovery -- Chapter 14. Investigating the Role of Tau Proteins in Alzheimers Disease-From Typical Functioning MAPs to Aberrant Fibrillary Deposits in the Brain -- Chapter 15. The Overview of Drugs Used in Alzheimers Disease and Their Molecular Targets
Summary This book explains the fundamental characteristics and biofunctionality of Alzheimers Disease drug targets and provides up-to-date information on the full range of their biomedical applications. An introductory section gives an overview of the recent developments related to drug targets identified and studied related to Alzheimers Disease and key developments from preclinical and clinical studies focusing on various molecular targets related to AD and dementia by subject experts all around the globe. Here, individual chapters address the progress and perspectives in human and non-human research, role of various biomarkers as an overview, advanced gene therapy, and novel compounds for therapeutic targets for Alzheimers disease. The book will be essential reading for graduate students, scientists, and engineers in any of the biomedical research fields in which efforts are being made to utilize novel drug targets and develop effective strategies for new drug targeting and delivery in Alzheimers disease treatment
Notes Includes index
Bibliography References -- Modified Investigation Tools and Techniques Useful in Alzheimerś Disease Research -- 1 Introduction -- 2 Pathophysiological Aspects of Alzheimerś Disease -- 3 In Vivo and In Vitro Techniques for Pathological Investigation of Alzheimerś Disease -- 4 In Vivo and Ex Vivo Animal Models for Alzheimerś Disease -- 4.1 In Vivo Models -- 4.1.1 In Vivo Transgenic Animal Models -- 4.1.2 In Vivo Non-transgenic Animal Models -- 4.1.3 In Vivo Chemically Induced Animal Models -- 4.1.4 Ex Vivo Animal Models -- 5 In Vitro Animal Models -- 5.1 Cell Lines
Notes Description based on online resource; title from digital title page (viewed on October 06, 2023)
Subject Alzheimer's disease -- Treatment
Drug targeting.
Drug Delivery Systems
Form Electronic book
Author Kumar, Dileep, editor
Patil, Vaishali M. editor
Wu, Dee (Professor at University of Oklahoma Health Sciences Center), editor.
Thorat, Nanasaheb, editor
ISBN 9819926572
9789819926572