PREFACE ; List of Contributors ; Should Physicians Screen for Dementia in the Primary Care Setting? ; INTRODUCTION; SECTION 1: SHOULD WE SCREEN FOR DEMENTIA?; Considerations in Screening for a Disease; Does Dementia Pass Muster as a Disease Worthy of Screening? ; CRITERION 1: How Prevalent and Costly is Alzheimer's disease?; CRITERION 2: Are Early Stages of Dementia not Obvious?; CRITERION 3: Are Screening Tools Cheap and Effective?; CRITERION 4: Does the Potential Harm from a False Positive or False Negative Test Outweigh the Positive Benefit from Screening?
Criterion 5: Does Earlier Diagnosis of Dementia or Cognitive Impairment Make a Difference?Potential Non-Disease Indirect Benefits of Screening for Dementia; Potential Benefit of Early Detection #1: Alerting Physician to Potential Medication Compliance Problems; Potential Benefit of Early Detection #2: Alerting Physicians to the Risk of Post-Operative Delirium; Potential Benefit of Early Detection #3: Additional Time for Family Planning; Potential Benefit of Early Detection #4: Assessing Patient's Competence at Work and Managing Finances
Potential Benefit of Early Detection #5: Identifying Unsafe Drivers Before it is too latePotential Benefit #6-Identification of Potentially Reversible Dementias-and Reversing Them; Potential Benefit #7: Identification of Patients for Research Program Participation; Potential Benefit #8: Establishment of a Cognitive Baseline; The Key Question: Can Earlier Intervention in Dementia Make a Difference?; SECTION 2: BEDSIDE TESTS FOR DEMENTIA SCREENING ; The Mini-Mental State [44]; Montreal Cognitive Assement (MoCA) [47]; The Clock Draw Test; The Mini-Cog [58]
Buschke's Memory Impairment Screen [61]Semantic and Lexical Fluency Tasks as Screening Tools; The Hopkins Verbal Learning Test (HVLT) [71]; The Q & E (Quick and Easy); CONCLUSION; NOTES; CONFLICT OF INTEREST; ACKNOWLEDGEMENTS; REFERENCES; Endothelial Dysfunction and Chronic Low-Grade Inflammation as Potential Therapeutic Targets in Dementia Disorders ; INTRODUCTION; Endothelial Dysfunction and Chronic Low-Grade Inflammation as a Possible Link between Cardiometabolic Disorders and Dementia; Endothelial Dysfunction and Dementia
Treatment Options Targeting Endothelial Dysfunction and Chronic Low-Grade Inflammation in Dementia DisordersEndothelin Receptor Antagonists; Anti-Inflammatory Drugs; Nonsteroidal Anti-Inflammatory Drugs ; Cytokine Suppressive Anti-Inflammatory Drugs; CONCLUSION; ACKNOWLEDGEMENTS; CONFLICT OF INTEREST; REFERENCES; Recent Clinical Developments in Alzheimer's Disease ; INTRODUCTION; Therapeutic Strategies and Clinical Trials; Cholinergic Hypothesis; Amyloid Cascade Hypothesis; Inflammation in AD ; Metal Dyshomeostasis in AD; Future Development: Challenges and Recent Advances
