| Description |
1 online resource (xv, 567 pages) : illustrations |
| Series |
Drug discovery series |
|
Drug discovery series.
|
| Contents |
Filamentous bacteriophage structure and biology -- Vectors and modes of display -- Methods for the construction of phage-displayed libraries -- Selection and screening strategies -- Leveraging synthetic phage-antibody libraries for panning on the mammalian cell surface -- Phage libraries for developing antibody-targeted diagnostics and vaccines -- Exploring protein-protein interactions using peptide libraries displayed on phage -- Substrate phage display -- Mapping intracellular protein networks -- High-throughput and high-content screening using peptides -- Engineering protein folding and stability -- Identification of natural protein-protein interactions with cDNA libraries -- Mapping protein functional epitopes -- Selections for enzymatic catalysts -- Antibody humanization and affinity maturation using phage display -- Antibody libraries from immunized repertoires -- Naive antibody libraries from natural repertoires -- Synthetic antibody libraries -- Engineering antibody fragments for intracellular applications |
| Summary |
The first and only guide to showcase the impact of phage display technology on drug discovery, this reference details the theories, principles, and methods impacting the field and demonstrates applications for peptide phage display, protein phage display, and the development of novel antibodies. Highlighting the current and future role of phage display in the development of protein therapeutics, this book provides a comprehensive overview that will prove invaluable to anyone researching recombinant antibodies |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (EBSCO; viewed on February 27, 2015) |
| Subject |
Bacteriophages.
|
|
Microbial biotechnology.
|
|
Pharmaceutical biotechnology.
|
|
Viral proteins.
|
|
Affinity chromatography.
|
|
Peptides -- Biotechnology
|
|
Proteins -- Biotechnology
|
|
Pharmaceutical chemistry.
|
|
Bacteriophages
|
|
Viral Proteins
|
|
Chromatography, Affinity
|
|
Biotechnology
|
|
Chemistry, Pharmaceutical
|
|
Drug Discovery
|
|
Peptide Library
|
|
bioengineering.
|
|
SCIENCE -- Life Sciences -- Biology.
|
|
SCIENCE -- Life Sciences -- Microbiology.
|
|
Pharmaceutical chemistry
|
|
Affinity chromatography
|
|
Bacteriophages
|
|
Microbial biotechnology
|
|
Peptides -- Biotechnology
|
|
Pharmaceutical biotechnology
|
|
Proteins -- Biotechnology
|
|
Viral proteins
|
| Form |
Electronic book
|
| Author |
Sidhu, Sachdev S., editor.
|
|
Geyer, Clarence Ronald, editor.
|
| ISBN |
9781439836507 |
|
1439836507 |
|
