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Book Cover
Author Kiseleva, Irina

Title Influenza
Published Sharjah : Bentham Science Publishers, 2021


Description 1 online resource (214 p.)
Contents Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Foreword -- Preface -- Historical Aspects -- INTRODUCTION -- THE FIRST INFLUENZA VIRUSES -- MODELS FOR STUDYING INFLUENZA -- The Right Choice of Anesthetic for Animal Study -- Standardization of the Infectious Dose -- The Right Choice of the Virus as a Model for Research -- SUBSTRATES FOR INFLUENZA VIRUS CULTIVATION -- Experimental Animals -- Embryonated Chicken Eggs -- Tissue Culture -- LABORATORY METHODS FOR DIAGNOSING INFLUENZA -- Virus Culturing by Virological Methods -- Serological Diagnosis
Molecular Identification -- Rapid Influenza Diagnostic Tests (RIDTs) -- CONCLUDING REMARKS -- REFERENCES -- Life Cycle of Influenza Virus -- INTRODUCTION -- GENOME AND CAPSID STRUCTURE -- REPLICATION IN HOST CELL -- The Entry into the Cell -- Endocytosis and Intracellular Migration of Virus-Containing Endosomes -- Transcription and Replication of the Viral Genome -- Translation -- Export of vRNA -- Post-Translation Modifications -- The Transport of Viral Proteins to the Plasma Membrane -- Packaging and Budding -- MOLECULAR MECHANISMS OF ATTENUATION -- Basic About Cold-Adapted LAIVs
What Role Do Mutations/Mutated Genes Play in Attenuation? -- An Alternative Method of Attenuation of LAIV -- MOLECULAR MECHANISMS OF VIRULENCE -- HA and NA as Determinants of Pathogenicity -- Polymerase Complex as a Determinant of Pathogenicity and Transmissibility -- NS1 Protein as a Determinant of Pathogenicity -- ARE ATTENUATION AND PATHOGENICITY OF THE INFLUENZA VIRUS TWO SIDES OF THE SAME COIN? -- CONCLUDING REMARKS -- REFERENCES -- Influenza Virus Ecology and Evolution -- INTRODUCTION -- INFLUENZA VIRUS RESERVOIRS -- THE ORIGIN AND EVOLUTION OF HUMAN INFLUENZA VIRUSES
The Genome Evolution -- Antigenic Evolution of Influenza Viruses: Shift and Drift -- Influenza Pandemics -- Influenza Epidemics -- Influenza Viruses with Pandemic Potential -- EVOLUTIONARY VARIABILITY OF INFLUENZA VIRUS PROPERTIES AS A FACTOR OF HOST-PATHOGEN INTERACTIONS -- Evolution of Influenza Viruses Based on Their Sensitivity to Replication Temperature -- Cyclical Nature of Evolutionary Variability of Virus Properties -- CONCLUDING REMARKS -- REFERENCES -- Influenza Prophylaxis and Treatment -- INTRODUCTION -- PAST, PRESENT, AND FUTURE OF INFLUENZA VACCINES
Substrates for Influenza Vaccine Development -- Conventional Egg-Derived Influenza Vaccines -- Immune Response to Conventional Egg-Derived Influenza Vaccines -- Cell Culture-Derived Influenza Vaccines -- Synthetic Influenza Vaccines -- Cross-Protection Potency of Influenza Vaccines -- PAST, PRESENT, AND FUTURE OF INFLUENZA CHEMOTHERAPY -- Direct-Acting Antivirals -- Resistance to Direct-Acting Antivirals: Bad or Good? -- Indirectly Acting Antivirals (Host-Directed Therapies) -- Antibody-Based Therapeutics -- CONCLUDING REMARKS -- REFERENCES -- Reasons for Insufficient Control of Influenza
Notes Description based upon print version of record
Form Electronic book
Author Larionova, Natalie
ISBN 9781681088440