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Title Matrix proteases in health and disease / edited by Niels Behrendt
Published Weinheim : Wiley-VCH, ©2012
Online access available from:
Wiley Online Books    View Resource Record  


Description 1 online resource (xxi, 394 pages) : illustrations
Contents Matrix Proteases in Health and Disease; Copyright Page; Contents; Preface; List of Contributors; Introduction; 1 Matrix Proteases and the Degradome; 1.1 Introduction; 1.2 Bioinformatic Tools for the Analysis of Complex Degradomes; 1.3 Evolution of Mammalian Degradomes; 1.3.1 Human Degradome; 1.3.2 Rodent Degradomes; 1.3.3 Chimpanzee Degradome; 1.3.4 Duck-Billed Platypus Degradome; 1.3.5 Other Degradomes; 1.4 Human Diseases of Proteolysis; 1.5 Matrix Proteases and Their Inhibitors; Acknowledgments; References; 2 The Plasminogen Activation System in Normal Tissue Remodeling; 2.1 Introduction
2.2 Biochemical and Enzymological Fundamentals2.2.1 Plasminogen; 2.2.2 Regulation of the Plasminogen Activation System; 2.3 Biological Roles of the Plasminogen Activation System; 2.3.1 Congenital Plasminogen Deficiencies; 2.3.2 Intravascular Fibrinolysis; 2.3.3 Extravascular Fibrinolysis -- Ligneous Conjunctivitis; 2.3.4 Congenital Inhibitor Deficiencies; 2.4 Tissue Remodeling Processes; 2.4.1 Wound Healing; 2.4.2 Vascular Remodeling; 2.4.3 Fibrosis; 2.4.4 Nerve Injury; 2.4.5 Rheumatoid Arthritis; 2.4.6 Complex Tissue Remodeling; 2.4.7 Angiogenesis; 2.4.8 uPAR -- Cinderella Finds Her Shoe
2.5 ConclusionsReferences; 3 Physiological Functions of Membrane-Type Metalloproteases; 3.1 Introduction; 3.2 Historical Perspective; 3.3 Activation of the Activator; 3.4 Potential Roles of MT-MMPs and Discovery of a Human MMP Mutation; 3.5 MT-MMP Function?; 3.6 Physiological Roles of MT1-MMP in the Mouse; 3.7 MT1-MMP Function in Lung Development; 3.8 MT1-MMP Is Required for Root Formation and Molar Eruption; 3.9 Identification of Cooperative Pathways for Collagen Metabolism; 3.10 MT-MMP Activity in the Hematopoietic Environment; 3.11 Physiological Role of MT2-MMP
3.12 MT-Type MMPs Work in Concert to Execute Matrix Remodeling3.13 MT4-MMP -- an MT-MMP with Elusive Function; 3.14 MT5-MMP Modulates Neuronal Growth and Nociception; 3.15 Summary and Concluding Remarks; Acknowledgment; References; 4 Bone Remodeling: Cathepsin K in Collagen Turnover; 4.1 Introduction; 4.2 Proteolytic Machinery of Bone Resorption and Cathepsin K; 4.3 Specificity and Mechanism of Collagenase Activity of Cathepsin K; 4.4 Role of Glycosaminoglycans in Bone Diseases; 4.5 Development of Specific Cathepsin K Inhibitors and Clinical Trials; 4.6 Off-Target and Off-Site Inhibition
4.7 ConclusionAcknowledgments; References; 5 Type-II Transmembrane Serine Proteases: Physiological Functions and Pathological Aspects; 5.1 Introduction; 5.2 Functional/Structural Properties of TTSPs; 5.3 Physiology and Pathobiology; 5.3.1 Hepsin/TMPRSS Subfamily; 5.3.2 Corin Subfamily; 5.3.3 Matriptase Subfamily; 5.3.4 HAT/DESC1 Subfamily; 5.3.5 TTSPs in Cancer; References; 6 Plasminogen Activators in Ischemic Stroke; 6.1 Introduction; 6.2 Rationale for Thrombolysis after Stroke; 6.2.1 Clinical Trials: Overview; 6.3 Preclinical Studies
Summary Presenting a comprehensive overview of the multifaceted field of proteases in the extracellular matrix environment, this reference focuses on the recently elucidated functions of complex proteolytic systems in physiological and pathological tissue remodeling. The proteases treated include both serine proteases such as plasminogen activators and TTSPs, metalloproteases such as MMPs and ADAMS and cysteine protease cathepsins. The text specifically addresses the role of extracellular proteases in cancer cell invasion, stroke and infectious diseases, describing the basic biochemistry behind these
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Extracellular matrix.
Proteolytic enzymes -- Physiological effect
Extracellular Matrix -- enzymology
Peptide Hydrolases
Extracellular Matrix
MEDICAL -- Histology.
Extracellular matrix
Extrazelluläre Matrix
Form Electronic book
Author Behrendt, Niels
ISBN 9783527649327
9781299157118 (MyiLibrary)
1299157114 (MyiLibrary)