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Title Cytoskeleton and human disease / Maria Kavallaris, editor
Published [Totowa, N.J.] : Humana Press, ©2012


Description 1 online resource (xxiv, 453 pages) : illustrations (some color)
Contents Part 1. Basics of the Cytoskeleton -- ACTIN / Vera Dugina, Richard Arnoldi, Paul A. Janmey and Christine Chaponnier -- Microtubules / Pavel Dráber and Eduarda Dráberová -- The Kinesin Superfamily / Linda Wordeman -- Basics of the Cytoskeleton: Myosins / Omar A. Quintero, Judy E. Moore and Christopher M. Yengo -- Part 2. Actin and Disease -- The Actin Cytoskeleton and Membrane Organisation in T Lymphocytes / Rhea Cornely, Thomas Grewal and Katharina Gaus -- Thin Filament Diseases of Striated Muscle / Anthony J. Kee and Edna C. Hardeman -- Filamins and Disease / Stephen P. Robertson and Philip B. Daniel -- LIM Kinase and Cancer Metastasis / Alice Schofield and Ora Bernard -- Actin Mutations and Deafness / Matías Morín, Fernando Mayo, Felipe Moreno and Miguel A. Moreno-Pelayo -- Therapeutic Targeting of the Actin Cytoskeleton in Cancer / Teresa Bonello, Jason Coombes, Galina Schevzov, Peter Gunning and Justine Stehn
Part 3. Microtubules and Disease -- Microtubules as a Target in Cancer Therapy / April L. Risinger and Susan L. Mooberry -- Microtubules, Drug Resistance, and Tumorigenesis / Joshua A. McCarroll and Maria Kavallaris -- Posttranslational Modifications of Tubulin / Suzan K. Chao, Chia-Ping H. Yang and Susan Band Horwitz -- Stathmin and Cancer / Dominic Chi Hiung Ng and Frances Byrne -- The Biology and Pathobiology of Tau Protein / Garth F. Hall -- Tubulin-Related Malformations of Cortical Development / Xavier H. Jaglin, Jamel Chelly and Nadia Bahi-Buisson -- Part 4. Intermediate Filaments and Disease -- Spectrins in Human Diseases / Marie-Christine Lecomte -- Laminopathies / Nadir M. Maraldi and Giovanna Lattanzi -- Desmin and Heart Disease / J. Scott Pattison and Jeffrey Robbins -- Neurodegenerative Diseases and Intermediate Filaments / Rodolphe Perrot and Jean-Pierre Julien
Summary The cytoskeleton is made up of a large variety of specialized proteins and is a highly dynamic system that is involved in the majority of key cellular events. It is now clear that the cytoskeleton is often associated, and has diverse roles in human disease.¡ Emerging understanding of the molecular and cellular events that drive cytoskeletal mediated disease including cancer, heart disease, myopathies, neurodegenerative diseases and skin disorders, are also helping shape targeted therapeutic approaches to treat these diseases. ¡ Cytoskeleton and Human Disease Book Summary reviews the key components, mechanisms and clinical implications of cytoskeletal defects in disease. Contributed by leading investigators in their respective fields, the chapters include topics associated with the basics of the cytoskeleton, actin-associated disease states, microtubule-associated disease states and intermediate filament-associated disease states. ¡ This authoritative volume is intended for a wide audience of clinicians, researchers and students with an interest in the application of biomedical research to the understanding and management of disease states associated with the cytoskeleton
Analysis Life sciences
Cell cycle
Cell Biology
Cell Cycle Analysis
Cell Physiology
Biochemistry, general
Cancer Research
humane ziekten
human diseases
cellular biology
Human Pathology
Humane pathologie
Bibliography Includes bibliographical references and index
Subject Cytoskeleton.
Pathology, Cellular.
Cytoskeleton -- pathology
Cytoskeleton -- genetics
MEDICAL -- Histology.
Pathology, Cellular
Form Electronic book
Author Kavallaris, Maria
ISBN 9781617797880