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Title P53 / [edited by] Ayeda Ayed, Theodore Hupp
Published Austin, Texas, USA : Landes Bioscience ; New York, New York, USA : Springer Science+Business Media, [2010]


Description 1 online resource (189 pages) : illustrations (some color)
Series Molecular biology intelligence unit
Molecular biology intelligence unit (Unnumbered : 2003)
Contents TP53 mutations in human cancers : selection versus mutagenesis / Magali Olivier, Audrey Petitjean, Claude Caron de Fromentel, and Pierre Hainaut -- Lessons on p53 from mouse models / Dadi Jiang and Laura D. Attardi -- TP63, TP73 : the guardian's elder brothers / Stephanie Courtois, Pierre Hainaut, and Claude Caron de Fromentel -- The regulation of p53 protein function by phosphorylation / Nicola J. Maclaine and Theodore Hupp -- The p53Mdm2 loop : a critical juncture of stress response / Yaara Levav Cohen, Zehavit Goldberg, Osnat Alsheich Bartok, Valentina Zuckerman, Sue Haupt, and Ygal Haupt -- Cooperation between MDM2 and MDMX in the regulation of p53 / Jeremy Blaydes -- Regulation and function of the original p53inducible p21 gene / Jennifer A. Fraser -- P53 localization / Carl G. Maki -- Modes of p53 interactions with DNA in the chromatin context / Vladana Vukojevic, Tatiana Yakovleva, and Georgy Bakalkin -- p53's dilemma in transcription : analysis by microarrays / Karuppiah Kannan, Gideon Rechavi, and David Givol -- Tumor viruses and p53 / Nobuo Horikoshi -- p53 and immunity / Vikram Narayan, Sarah E. Meek, and Kathryn L. Ball
Summary "This volume, 'p53', was developed primarily as a resource for access to key ideas in the field that have developed over the years including how transgenics have been used to study p53, how clinical genetics have identified and studied mutations in p53 found in human cancers, how p53 can be regulated by post-translational modification, and how key drug targets have been defined, namely MDM2, which has provided fundamental approaches for defining how p53 can be activated with potentially therapeutic effect. The key concepts in the chapters included provide a perspective on key paradigms in the p53 field"--Provided by publisher
Analysis biomedische wetenschappen
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject p53 antioncogene.
p53 protein.
Cell Transformation, Neoplastic -- genetics
Genes, p53
Tumor Suppressor Protein p53
p53 antioncogene
p53 protein
Form Electronic book
Author Ayed, Ayeda, 1962- editor.
Hupp, Theodore, 1969- editor.
LC no. 2010046107
ISBN 9781441982315