Limit search to available items
Book Cover

Title Dipeptidyl aminopeptidases : basic science and clinical applications / Uwe Lendeckel, Dirk Reinhold, Ute Bank, editors
Published New York : Springer, ©2006


Description 1 online resource (xxiv, 239 pages) : illustrations
Series Advances in experimental medicine and biology ; v. 575
Advances in experimental medicine and biology ; v. 575.
Contents Topic I. Structure and function. Peptide substrates of dipeptidyl peptidases / Inger Brandt [and others]. Phosphorus-containing inhibitors of proteolytic enzymes / Angel Stöckel-Maschek [and others]. Biochemical properties of recombinant prolyl dipeptidases DPP-IV and DPP8 / Xin Chen. Prediction of dipeptidyl peptidase (DP) 8 structure by homology modelling / Melissa R. Pitman, R. Ian Menz, and Catherine A. Abbott -- Topic II. DPIV-related enzymes. Structure and function in dipeptidyl peptidase IV and related proteins / Mark D. Gorrell [and others]. Expression and function of dipeptidyl peptidase IV and related enzymes in cancer / Petr Busek [and others]. DP8 and DP9 have extra-enzymatic roles in cell adhesion, migration, and apoptosis / Denise M.T. Yu [and others]. In vivo effects of a potent, selective DPPII inhibitor: UAMC00039 is a possible tool for the elucidation of the physiological function of DPPII / Marie-Berthe Maes [and others]. Expression of dipeptidyl peptidase IV-like enzymes in human peripheral blood mononuclear cells / Sabine Wrenger [and others]. Dipeptidyl peptidase 8 has post-proline dipeptidyl aminopeptidase and prolyl endopeptidase activities / Joohong Park [and others]. Prolyl endopeptidase cleaves the apoptosis rescue peptide humanin and exhibits and unknown post-cysteine cleavage specificity / Joachim Wolfgang Bär [and others]. Distribution of dipeptidyl peptidase IV-like activity enzymes in canine and porcine tissue sections by RT-PCR / Leona Wagner [and others] -- Topic III. Metabolic disorders. Relative contribution of incretins to the glucose lowering effect of DP IV inhibitors in type 2 diabetes mellitus (T2DM) / Simon A. Hinke, Raymond A. Pederson, and Christopher H.S. McIntosh. Dipeptidyl peptidase IV: a molecular switch of vascular actions of neuropeptide Y / Lijun Li, Hans-Ulrich Demuth, and Zofia Zukowska -- Topic IV. Immune disorders. Dipeptidylpeptidase IV (DPIV) and alanyl-aminopeptidases (AAPs) as a new target complex for treatment of autoimmune and inflammatory diseases: proof of concept in a mouse model of colitis / Ute Bank [and others]. Dipeptidyl peptidases and inflammatory bowel disease / Catherine A. Abbott [and others]. Possible role of DP IV inhibitors in acne therapy / Anja Thielitz [and others]. Dipeptidyl peptidase-IV activity and/or structure homologs (DASH): contributing factors in the pathogenesis of rheumatic diseases? / Eva Balaziova [and others] -- Topic V. Neuronal diseases. Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation / Aliza Biton [and others]. CD26/DP IV in T cell activation and autoimmunity / Vera Preller [and others]. DPIV/CD26 and FAP in cancer: a tale of contradictions / Melanie L. Sulda, Catherine A. Abbott, and Martin Hildebrandt. Type-II transmembrane prolyl dipeptidases and matrix metalloproteinases in membrane vesicles of active endothelial cells / Monica Salamone [and others]. Extra-enzymatic roles of DPIV and FAP in cell adhesion and migration on collagen and fibronectin / Xin M. Wang [and others]. Role of neuropeptide Y and dipeptidyl peptidase IV in regulation of Ewing's sarcoma growth / Joanna Kitlinska [and others]. The role of CD26/DPP IV in preservation of early pulmonary graft function / Florian Johannes Jung [and others]
Summary Dipeptidyl Aminopeptidases exert a modulatory role at an interface between immune mechanisms, metabolic responses, and neuroendocrine pathways. This book focuses on various topics, including DP IV and related enzymes in: expression and function, metabolic disorders, immune mechanisms and immune disorders, neuronal diseases and cancer, and more
Analysis suikerziekte
infectious diseases
metabolic disorders
biomedische wetenschappen
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes Print version record
In Springer e-books
Subject CD antigens -- Congresses
Aminopeptidases -- Congresses
CD26 antigen.
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases -- physiology
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases -- therapeutic use
Dipeptidyl Peptidase 4
MEDICAL -- Immunology.
Dipeptidyl Peptidases -- physiology.
Dipeptidyl Peptidases -- therapeutic use.
Antigens, CD26.
CD antigens.
Sciences de la vie.
CD26 antigen
CD antigens
Genre/Form proceedings (reports)
Conference papers and proceedings
Conference papers and proceedings.
Actes de congrès.
Form Electronic book
Author Lendeckel, Uwe
Reinhold, Dirk.
Bank, Ute.
International Conference on Dipeptidyl Aminopeptidases (2nd : 2005 : Magdeburg, Germany)
ISBN 9780387328249