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Title The serotonin receptors : from molecular pharmacology to human therapeutics / edited by Bryan L. Roth
Published Totowa, N.J. : Humana Press, ©2006


Description 1 online resource (xvii, 618 pages) : illustrations
Series The receptors
Receptors (Series)
Contents Molecular biology and genomic organization of G protein-coupled serotonin receptors -- Structure and function reveal insights in the pharmacology of 5-HT receptor subtypes -- Polymorphic and posttranscriptional modifications of 5-HT receptor structure: functional and pathological implications -- Strategies for the development of selective serotonergic agents -- 5-HT receptor signal transduction pathways -- Agonist-directed trafficking of 5-HT receptor-mediated signal transduction -- Identification of 5-HT2 and 5-HT4 receptor-interacting proteins: a proteomic approach -- 5-HT receptor-associated proteins (FRAPs): relevance for targeting, trafficking, and signal transduction -- Cellular and subcellular localization of serotonin receptors in the central nervous system -- Chemical neuroanatomy of 5-HT receptor subtypes in the mammalian brain -- Modulation of the neuronal activity and neurotransmitter release by 5-HT1A and 5-HT1B/1D receptors -- Electrophysiology of 5-HT2A receptors and relevance for hallucinogen and atypical antipsychotic drug actions -- The emergence of 5-HT2B receptors as targets to avoid in designing and refining pharmaceuticals -- The 5-HT3 receptor -- 5-HT3 and 5-HT4 receptors as targets for drug discovery for dementia -- Electrophysiological properties of Gas-coupled 5-HT receptors (5-HT4, 5-HT6, 5-HT7) -- 5-HT6 receptors as targets for the treatment of cognitive deficits in schizophrenia -- 5-HT7 receptors as favorable pharmacological targets for drug discovery -- Serotonin system gene knockouts: a story of mice with implications for man -- Effects of serotonin-related gene deletion on measures of anxiety, depression, and neurotransmission
Summary The recent cloning and identification of a large number of serotonin (5-HT) receptors-a major family of therapeutic targets-holds out the possibility of developing novel, subtype-selective 5-HT receptor agonists and antagonists for use as psychiatric, cardiovascular, and neurological medications. In The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics, leading experts comprehensively examine our current understanding of the molecular and structural biology of 5-HT receptors and their pharmacological use. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction. Comprehensive and state of the art, The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics provides an illuminating "snapshot" of the 5-HT receptor field today and prospects for the future, taking it from the genomic to a systems level of understanding
Bibliography Includes bibliographical references and index
Subject Serotonin -- Receptors
Serotonin -- Physiological effect
Serotoninergic mechanisms.
Receptors, Serotonin -- physiology
Receptors, Serotonin -- therapeutic use
Serotonin Agents -- pharmacology
Serotonin Agents -- therapeutic use
MEDICAL -- Neuroscience.
PSYCHOLOGY -- Neuropsychology.
Serotonin -- Physiological effect.
Serotoninergic mechanisms.
Receptors, Serotonin -- physiology.
Receptors, Serotonin -- therapeutic use.
Serotonin Agents -- pharmacology.
Serotonin Agents -- therapeutic use.
Serotonin -- Receptors.
Serotonin -- Physiological effect
Serotonin -- Receptors
Serotoninergic mechanisms
Form Electronic book
Author Roth, Bryan L.
ISBN 1588295680