Limit search to available items
Book Cover
Author Kashyap, Amita, author

Title Bioinformatics of non small cell lung cancer and the ras proto-oncogene / Amita Kashyap, D. Bujamma, Naresh Babu M
Published Heidelberg : Springer-Verlag, [2015]


Description 1 online resource (vii, 72 pages) : illustrations (some color)
Series Springer Briefs in applied sciences and technology. Forensic and medical bioinformatics
SpringerBriefs in applied sciences and technology. Forensic and medical bioinformatics
Contents Introduction -- Review of Literature -- Materials and Methods (Tools and Databases) -- Flowchart -- Conclusion.-References
Summary Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10-30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken
Analysis engineering
toegepaste wiskunde
applied mathematics
computational science
biomedische techniek
biomedical engineering
Engineering (General)
Techniek (algemeen)
Bibliography Includes bibliographical references
Notes Online resource; title from PDF title page (Ebsco, viewed September 17, 2014)
Subject Bioinorganic chemistry.
Small cell lung cancer.
Small Cell Lung Carcinoma
Chemistry, Bioinorganic
Carcinoma, Small Cell
SCIENCE -- Life Sciences -- Biochemistry.
Bioinorganic chemistry.
Small cell lung cancer.
Form Electronic book
Author Bujamma, D., author
M., Naresh Babu (Muppalaneni), author
ISBN 9789814585088