| Description |
1 online resource (240 pages) : illustrations |
| Contents |
Cover ; Title page; Copyright page; Dedication; Contents; List of Contributors; Preface; List of Abbreviations; Introductiona; Chapter 1 -- The Pituitary Gland: Anatomy, Physiology, and its Function as the Master Gland; 1 -- Introduction; 2 -- History; 3 -- Embryology; 4 -- Anatomy; 4.1 -- Histology; 4.2 -- Hypothalamus; 4.3 -- Vascular Anatomy; 4.4 -- Surgical Anatomy; 4.4.1 -- Nasal Cavity Anatomy; 4.4.2 -- Sphenoid Sinus Anatomy; 4.5 -- Radiographic Anatomy; 5 -- Physiology; 5.1 -- Hypothalamic Physiology; 5.1.1 -- Hypothalamus-Pituitary-Adrenal Axis; 5.1.2 -- Hypothalamus-Pituitary-Thyroid Axis |
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5.1.3 -- Hypothalamus-Pituitary-Growth Hormone Axis; 5.1.4 -- Hypothalamus-Pituitary-Gonadal Axis; 5.1.4.1 -- Effects on Men; 5.1.4.2 -- Effects on Women; 5.1.5 -- Lactotroph Axis; 5.2 -- Posterior Pituitary Function; 5.3 -- Intermediate Gland Function; 6 -- Homeostasis; 7 -- Hypopituitarism; 8 -- Conclusions; References; Chapter 2 -- Epidemiology and Etiology of Cushing's Disease; 1 -- Introduction; 2 -- Epidemiology of Cushing's Disease; 2.1 -- Incidence and Prevalence; 2.1.1 -- Population-Based Data; 2.1.2 -- Hypercortisolism in Patients with Incidentally Found Pituitary Masses |
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2.1.3 -- "Occult" Cushing's Disease in Patients with Diabetes Mellitus, Hypertension, Polycystic Ovary Syndrome, Obesity, an ... 2.2 -- Mortality; 2.3 -- Long-Term Morbidity and Quality of Life; 3 -- Etiology of Cushing's Disease; 3.1 -- Mutations in the Deubiquitinase Gene (USP8); 3.2 -- Multiple Endocrine Neoplasia 1 Syndrome; 3.3 -- Mutations in the Aryl-hydrocarbon Receptor Interacting Protein (AIP) Gene; 3.4 -- Other Gene Mutations; 3.4.1 -- Mutations in the DICER1 (Ribonuclease Type III) Gene; 3.4.2 -- Mutations in Cyclin-Dependent Kinase Inhibitor Subtype 1B Gene; 3.4.3 -- Mutations in the GR Gene |
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3.4.4 -- Mutations in the p53 Gene; 3.5 -- Gene and Protein Expression Abnormalities in Corticotropinomas; 4 -- Conclusions; Disclosures; References; Chapter 3 -- Physical Presentation of Cushing's Syndrome: Typical and Atypical Presentations; 1 -- Introduction; 2 -- Symptoms of Cushing's disease; 2.1 -- Subjective Symptoms; 2.2 -- Objective Symptoms; 2.3 -- Atypical Symptoms; 3 -- Signs of Cushing's disease; 4 -- Comorbidities associated with Cushing's syndrome; 4.1 -- Diabetes Mellitus; 4.2 -- Hypertension; 4.3 -- Sleep Disturbances; 4.4 -- Osteoporosis and Bone Fractures; 4.5 -- Depression and Psychosis |
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4.6 -- Memory and Cognitive Function; 5 -- Cyclical Cushing's syndrome; 6 -- Cushing's syndrome in athletes; 7 -- Pseudo-Cushing's disease; 8 -- Cushing's syndrome in children and adolescents; 9 -- Conclusions; Chapter 4 -- The Cognitive, Psychological, and Emotional Presentation of Cushing's Disease; 1 -- Introduction; 2 -- Cognitive and emotional aspects of Cushing's disease; 2.1 -- Clinical Presentations; 2.1.1 -- Effects on Psychological Health; 2.1.2 -- Effects on Sleep; 2.1.3 -- Effects on Cognitive Function; 3 -- Effects of glucocorticoid excess on brain structures; 3.1 -- Hippocampal Size and Atrophy |
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3.1.1 -- Animal Models |
| Summary |
Cushing's Disease: An Often Misdiagnosed and Not So Rare Disorder reviews the epidemiology of Cushing's, including statistics on the incidence and prevalence of this disease. There are discussions of the signs and symptoms and the most common co-morbidities, such as diabetes mellitus, hypertension, osteoporosis, amenorrhea, and infertility. Surgical, medical, and radiotherapeutic treatments, including indications, results, risks, and complications, are reviewed. Also featured is a chapter on the patient's perspective, coping with Cushing's, quality of life, and psychosomatic issues. This book is essential reading for the wide range of physicians who treat patients with Cushing's disease symptoms, as well as biomedical researchers who investigate the etiology and mechanisms of rare genetic diseases, in particular rare endocrine disorders |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Cushing's syndrome.
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Pituitary ACTH Hypersecretion
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Cushing Syndrome
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Cushing's syndrome
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| Form |
Electronic book
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| Author |
Laws, Edward R., editor
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Pace, Louise, writer of introduction
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| ISBN |
0128043903 |
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9780128043905 |
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