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Title Henipavirus : ecology, molecular virology, and pathogenesis / Benhur Lee, Paul A. Rota, editors
Published Berlin ; New York : Springer, ©2012


Description 1 online resource : illustrations (chiefly color)
Series Current topics in microbiology and immunology, 0070-217X ; v. 359
Current topics in microbiology and immunology ; v. 359.
Contents Introduction: Nipah Virus--Discovery and Origin / Kaw Bing Chua -- Ecological Aspects of Hendra Virus / Hume Field, Gary Crameri, Nina Yu-Hsin Kung and Lin-Fa Wang -- Epidemiology of Henipavirus Disease in Humans / Stephen P. Luby and Emily S. Gurley -- Molecular Virology of the Henipaviruses / Paul A. Rota and Michael K. Lo -- Henipavirus Receptor Usage and Tropism / Olivier Pernet, Yao E Wang and Benhur Lee -- Henipavirus Membrane Fusion and Viral Entry / Hector C. Aguilar and Ronald M. Iorio -- Clinical and Pathological Manifestations of Human Henipavirus Infection / K.T. Wong and C.T. Tan -- Henipaviruses in Their Natural Animal Hosts / D.J. Middleton and H.M. Weingartl -- Nipah and Hendra Virus Interactions with the Innate Immune System / Christopher F. Basler -- Animal Challenge Models of Henipavirus Infection and Pathogenesis / Thomas W. Geisbert, Heinz Feldmann and Christopher C. Broder -- Diagnosis of Henipavirus Infection: Current Capabilities and Future Directions / Lin-Fa Wang and Peter Daniels -- Immunization Strategies Against Henipaviruses / Christopher C. Broder, Thomas W. Geisbert, Kai Xu, Dimitar B. Nikolov and Lin-Fa Wang, et al
Summary Henipaviruses form a new genus of emerging paramyxoviruses that are the deadliest human pathogens within the Paramyxoviridae family. This volume deals with the many facets of henipavirus biology, and covers our current understanding regarding the ecology, molecular virology, and pathogenesis of henipavirus infections. It is an international effort written by a multidisciplinary panel of experts at the front lines of research into this lethal emerging group of paramyxoviruses. The first section introduces the epidemiology and ecology of Nipah and Hendra viruses in their respective endemic areas, including a first-hand account of the discovery of Nipah virus during its initial outbreak in Malaysia; the next section documents the molecular virology of henipaviruses, and the substantial advances made towards understanding the unique features of henipavirus entry and tropism; and this is followed by accounts of the clinical and pathologic features of henipavirus infections in their human and naturally infected animal hosts. The next sections on pathogenesis provide a comprehensive reference on how henipaviruses counteract the innate immune system, and the relevant pathogenic features in animal challenge models developed to test potential therapeutic strategies. The final sections describe our current and future capabilities for diagnosis and control, including an account of potentially effective immunization strategies that are currently being tested.¡ ¡ This book will not only serve as a useful reference for the henipavirus field; it will be useful to basic and animal virologists, ecologists, epidemiologists, physicians, and others interested in emerging infectious viral diseases, as it showcases the multidisciplinary efforts required to understand the genesis, spread and hopefully, control, of a group of lethal emerging zoonotic pathogens.¡¡
Analysis Medicine
Medical virology
Wildlife management
Bibliography Includes bibliographical references and index
Notes English
Subject Paramyxoviruses.
Medical virology.
Virus diseases.
Life sciences.
Physical sciences.
RNA viruses.
Vertebrate Viruses
Virus Diseases
Henipavirus -- physiology
Paramyxoviridae Infections
Biological Science Disciplines
Natural Science Disciplines
Mononegavirales Infections
RNA Virus Infections
Disciplines and Occupations
RNA Viruses
Henipavirus Infections
Henipavirus Infections -- physiopathology
Henipavirus -- pathogenicity
biological sciences.
physical sciences.
HEALTH & FITNESS -- Diseases -- Contagious.
MEDICAL -- Infectious Diseases.
Virus diseases
RNA viruses
Physical sciences
Life sciences
Medical virology
Form Electronic book
Author Lee, Benhur
Rota, Paul A
ISBN 9783642298196