A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus
NF-kappa B -- antagonists & inhibitors : The multiple therapeutic targets of A20 / edited by Christiane Ferran, MD, PhD, Department of Surgery, Division of Vascular and Endovascular Surgery, Center for Vascular Biology Research, and the Transplant Insitutue, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
