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Author Zhou, Shufeng, author

Title Cytochrome P450 2D6 : structure, function, regulation and polymorphism / Shufeng Zhou
Published Boca Raton : CRC Press LLC, [2016]


Description 1 online resource : color illustrations
Contents Chapter 1. Introduction to human cytochrome P450 superfamily -- chapter 2. Mammalian CYP2D members : a comparison of structure, function, and regulation -- chapter 3. Substrates of human CYP2D6 -- chapter 4. Inhibitors of human CYP2D6 -- chapter 5. Regulation of human CYP2D6 -- chapter 6. Structure and function of human CYP2D6 -- chapter 7. Clinical pharamcogenomics of human CYP2D6 -- chapter 8. General discussion about human CYP2D6
Summary "Cytochromes are proteins that catalyze electron transfer reactions of well-known metabolic pathways and are classified in various superfamilies. The CYP, or P450, superfamily accounts for 90% of the oxidative metabolism of clinical drugs. One member of this superfamily, P450 2D6 (or CYP2D6), singlehandedly metabolizes about 25% of all medications in the human liver. Cytochrome P450 2D6: Structure, Function, Regulation, and Polymorphism reviews the current knowledge of CYP2D6 as well as the maturing body of evidence indicating its significance to clinical and pharmacological researchers and practitioners. This book focuses on the critical role CYP2D6 plays in the human liver. It examines the genetic, epigenetic, physiological, pathological, and structural factors of the gene that govern the highly variable metabolism of a number of drugs in clinical use. It highlights the impact of the functional roles of CYP2D6 on clinical practice and drug development and also discusses implications for precise medicine, strategies to avoid adverse drug reactions, and paths for future research."-- Provided by publisher
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (EBSCO, viewed March 17, 2016)
Subject Cytochrome P-450 CYP2D6.
Cytochrome P-450 CYP2D6
SCIENCE -- Life Sciences -- Biochemistry.
Cytochrome P-450 CYP2D6
Form Electronic book
ISBN 9781466597884