| Description |
1 online resource (xxvi, 590 pages) : illustrations (some color) |
| Series |
Oxford clinical nephrology series |
|
Oxford clinical nephrology series.
|
| Contents |
Contributors; List of Abbreviations; Introduction; 1 Definition and classification of renal osteodystrophy and chronic kidney disease-mineral bone disorder (CKD-MBD); Renal osteodystrophy; Chronic kidney disease-mineral bone disorder; Conclusion; References; 2 New aspects of normal bone biology; Introduction; Osteoclasts; Osteoblasts; Osteocytes; Systemic hormones; Summary; References; 3 Osteocytes and mineral metabolism; Introduction; The osteoblast/osteocyte lineage; Osteocyte role in mineralization; Roles of osteocytes in the control of Pi homeostasis |
|
Osteocytes' role in phosphate dysregulation associated with CKDThe influence of CKD on osteocyte function; Summary; References; 4 Calcium-sensing receptors (CaSR) in kidney, bone, and vessels; Introduction; Expression, structure, and signaling of the extracellular CaSR; CaSR in the kidney; CaSR and bone; The CaSR and blood vessels; Summary; References; 5 Regulation of parathyroid hormone biosynthesis and gene expression; Introduction; Regulation of PTH expression by 1,25(OH)[sub(2)] vitamin D; Post-transcriptional regulation of PTH gene expression by calcium, phosphate, and CKD |
|
Fibroblast growth factor-23 and PTH gene expressionConclusions; References; 6 Abnormal parathyroid gland function in CKD; Introduction; Regulation of PTH gene transcription in CKD; Regulation of PTH release in CKD; Phosphate and abnormal PTH synthesis and secretion in CKD; Vitamin D and abnormal PTH synthesis and secretion in CKD; Abnormal PTH synthesis and secretion due to other factors; Post-transcriptional modulation of PTH synthesis in CKD; Changes in the intracellular and peripheral metabolism of PTH in CKD; Hyperplasia of parathyroid glands in CKD |
|
Parathyroid function and VDR polymorphismsControl of increased parathyroid mass; Parathyroid tissue apoptosis and necrosis; Summary; References; 7 PTHrP physiology and pathophysiology, and the PTH/PTHrP receptor; Introduction; Characteristics of the PTHrP gene; Regulation of PTHrP production; Processing and degradation of PTHrP; Physiological actions of PTHrP; Mechanisms of action of PTHrP; PTH/PTHrP receptor expression in renal osteodystrophy; Summary; References; 8 Vitamin D metabolism and action in CKD; Introduction; 25-Hydroxyvitamin D deficiency in CKD; Calcitriol production in CKD |
|
The vitamin D receptorEffects of declining 1,25-dihydroxyvitamin D on mineral metabolism; Non-traditional actions of vitamin D; Cardiac effects of calcitriol; Vitamin D and the immune system; Additional effects of vitamin D; Vitamin D and survival in CKD; Summary; References; 9 Growth factors and cytokines in renal bone disease; Introduction; The cells of bone; Bone remodeling; Effects of uremia on skeletal biology; References; 10 Bone histomorphometry in renal osteodystrophy; Historical perspective of renal osteodystrophy; Pathology of different forms of renal osteodystrophy |
| Summary |
This new edition is fully updated to reflect the most current thinking and understanding in the field, as presented by a team of international clinical experts |
| Notes |
Revised edition of: The spectrum of renal osteodystrophy / edited by Tilman Drüeke, Isidro B. Salusky. c2001 |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
|
Print version record |
| Subject |
Renal osteodystrophy.
|
|
Chronic Kidney Disease-Mineral and Bone Disorder
|
|
Renal Insufficiency, Chronic -- complications
|
|
HEALTH & FITNESS -- Diseases -- General.
|
|
MEDICAL -- Clinical Medicine.
|
|
MEDICAL -- Diseases.
|
|
MEDICAL -- Evidence-Based Medicine.
|
|
MEDICAL -- Internal Medicine.
|
|
Renal osteodystrophy
|
|
Chronische Niereninsuffizienz
|
|
Knochenstoffwechsel
|
|
Mineralstoffwechselstörung
|
| Form |
Electronic book
|
| Author |
Olgaard, Klaus.
|
|
Salusky, Isidro B.
|
|
Silver, Justin, 1943-
|
| ISBN |
9780191029325 |
|
0191029327 |
|
0191753351 |
|
9780191753350 |
|
