A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use
Buprenorphine -- Therapeutic use -- United States : Medications for opioid use disorder save lives / Committee on Medication-Assisted Treatment for Opioid Use Disorder ; Alan I. Leshner and Michelle Mancher, editors ; Board on Health Sciences Policy, Health and Medicine Division
