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Title Recent advances in thrombosis and hemostasis 2008 / K. Tanaka, E.W. Davie, eds. ; Y. Ikeda [and others], associate eds
Published Tokyo : Springer, ©2008


Description 1 online resource (xxi, 643 pages) : illustrations (some color)
Contents Part 1: Coagulation Mechanism. Structure and Functions of Fibrinogen and Fibrin / Michael W. Mosesson ; Vitamin K Cycles and y-Carboxylation of Coagulation Factors / Barrel W. Stafford and Christine M. Hebling ; Synthesis and Secretion of Coagulation Factor VIII / Michael U. Callaghan and Randal J. Kaufman ; Structure and Biological Function of Factor XI / Kazuo Fujikawa ; Structural Insights into the Life History of Thrombin / James A. Huntington ; A Molecular Model of the Human Prothrombinase Complex / Stephen J. Everse, Ty E. Adams, and Kenneth G. Mann ; Lipid Mediators and Tissue Factor Expression / Hiroyuki Takeya and Koji Suzuki ; Tissue Factor Pathway Inhibitor: Structure and Function / Hisao Kato ; Biology of an Antithrombotic Factor -- ADAMTS13 / Fumiaki Banno and Toshiyuki Miyata ; Antithrombin and Heparin Cofactor II: Structure and Functions / Takehiko Koide -- Part 2: Endothelial. Cells and Inflammation High-Mobility Group Box 1: Missing Link Between Thrombosis and Inflammation? / Takashi Ito, Ko-ichi Kawahara, Teruto Hashiguchi, and Ikuro Maruyama ; Coagulation, Inflammation, and Tissue Remodeling / Koji Suzuki, Tatsuya Hayashi, Osamu Taguchi, and Esteban Gabazza ; Structure and Function of the Endothelial Cell Protein C Receptor / Kenji Fukudome ; New Aspects of Antiinflamatory Activity of Antithrombin: Molecular Mechanism(s) and Therapeutic Implications / Naoaki Harada and Kenji Okajima -- Part 3: Platelets. Platelet Collagen Receptors / Stephanie M. Jung and Masaaki Moroi ; Positive and Negative Regulation of Integrin Function / Yoshiaki Tomiyama, Masamichi Shiraga, and Hirokazu Kashiwagi ; GPIb-Related SignaHng Pathways in Platelets / Yukio Ozaki ; Sphingosine 1-Phosphate as a Platelet-Derived Bioactive Lipid / Yutaka Yatomi ; Polymorphisms of Platelet Membrane Glycoproteins / Yumiko Matsubara, Mitsuru Murata, and Yasuo Ikeda ; Platelet Procoagulant Activity Appeared by Exposure of Platelets to Blood Flow Conditions / Shinya Goto -- Part 4: Tissue Proteolysis. Regulation of Cellular uPA Activity and Its Implication in Pathogenesis of Diseases / Soichi Kojima ; Role of tPA in the Neural System / Nobuo Nagai and Tetsumei Urano ; Role of Fibrinolysis in the Nasal System / Takayuki Sejima and Yoichi Sakata ; Role of Fibrinolysis in Hepatic Regeneration / Kiyotaka Okada, Shigeru Ueshima, and Osamu Matsuo ; Pathophysiology of Transglutaminases Including Factor FXIII / Akitada Ichinose
Part 5: Vascular Development and Regeneration. A Linkage in the Developmental Pathway of Vascular and Hematopoietic Cells / Jun K. Yamashita ; Atherosclerosis and Angiogenesis: Double Face of Neovascularization in Atherosclerotic Intima and Collateral Vessels in Ischemic Organs / Katsuo Sueishi, Mitsuho Onimaru, and Yutaka Nakashima -- Part 6: Hemorrhagic Diathesis. Hemophia A and Inhibitors / Midori Shima and Akira Yoshioka ; von Willebrand Disease: Diagnosis and Treatment / Masato Nishino -- Part 7: Other Topics of Thrombosis and Hemostasis. Age-Related Homeostasis and Hemostatic System / Kotoku Kurachi, Sumiko Kurachi, Toshiyuki Hamada, Emi Suenaga, Tatiana Bolotova, and Elena Solovieva ; Molecular Evolution of Blood Clotting Factors with Special Reference to Fibrinogen and von Willebrand Factor / Sadaaki Iwanaga, Soutaro Gokudan, and Jun Mizuguchi ; Snake Venoms and Other Toxic Components Affecting Thrombosis and Hemostasis / Yasuo Yamazaki and Takashi Morita ; Structures and Potential Roles of Oligosaccharides in Human Coagulation Factors and von Willebrand Factor / Taei Matsui, Jiharu Hamako, and Koiti Titani -- Part 8: Clinicals: Thrombosis-related Disorders and Recent Topics. Hypercoagulable States / Tetsuhito Kojima and Hidehiko Saito ; Etiopathology of the Antiphospholipid Syndrome / Tatsuya Atsumi, Olga Amengual, and Takao Koike ; Malignancy and Thrombosis / Hiroshi Kobayashi, Ryuji Kawaguchi, Yoriko Tsuji, Yoshihiko Yamada, Mariko Sakata, Seiji Kanayama, Shoji Haruta, and Hidekazu Oi ; Disseminated Intravascular Coagulation / Hideo Wada ; Current Clinical Status of Venous Thromboembolism in Japan / Mashio Nakamura, Takeshi Nakano, Satoshi Ota, Norikazu Yamada, Masatoshi Miyahara, Naoki Isaka, and Masaaki Ito ; Platelet Activity and Antiplatelet Therapy in Patients with Ischemic Stroke and Transient Ischemic Attack / Shinichiro Uchiyama, Tomomi Nakamura, Yumi Kimura, and Masako Yamazaki ; Clinical Role of Recombinant Factor Vila in Bleeding Disorders / Harold R. Roberts, Dougald M. Monroe, and Nigel S. Key ; Clinical Role of Protein S Deficiency in Asian Population / Naotaka Hamasaki and Taisuke Kanaji ; Atherothrombosis and Thrombus Propagation / Atsushi Yamashita and Yujiro Asada ; Thrombotic Microangiopathy / Yoshihiro Fujimura, Masanori Matsumoto, and Hideo Yagi
Summary Now more than ever, thrombotic and thromboembolic disorders as well as related diseases such as malignancies, arteriosclerosis, diabetes mellitus, hypertension, and obesity are the leading causes of morbidity and mortality. They have become urgent medical problems with serious economic consequences in industrialized and devel- ing countries alike. At the same time, the impact of molecular biology and genetics on our understanding of thrombosis and hemostasis is rapidly growing stronger as well as our knowledge of regeneration and development of specific tissues, organs, and embryos. Researchers are also constantly learning more about cardiovascular diseases as well as regulatory mechanisms for various intrinsic and extrinsic stimuli in viable tissues. In this volume, our intention has been to present the latest relevant information in molecular biology and genetics as well as the clinical implications of a better understanding of pathophysiology, novel diagnostic methodologies, and therapeutic applications for new methods of prevention in thrombosis/hemostasis and related disorders, including atherosclerosis. The dramatic advances in knowledge of thrombosis/hemostasis and vascular biology since the first publication of Recent Advances in Thrombosis and Fibrinolysis, edited with Japanese colleagues, in 1991, have required extensive revision in order to highlight and review recent progress in the field. The editors also gratefully welcome the seven distinguished non Japanese authors, who, with their valuable contributions on subjects beyond the coverage by Japanese authors, have made this new edition truly international
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Blood coagulation disorders.
Blood Coagulation Disorders
MEDICAL -- Cardiology.
Blood coagulation disorders.
Blood coagulation disorders
Form Electronic book
Author Tanaka, Kenzō, 1922-2015.
Davie, E. W. (Earl W.)
Ikeda, Yasuo, 1944-
ISBN 9784431788478